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IRCT138710241548N1 IRCT 2009-09-09 Deputy of Research of Shiraz University of Medical Sciences Evaluation of the effect of an herbal medication on severity, frequency and duration of hot flashes in menopausal women The effect of St John's Wort on severity, frequency and duration of hot flashes in peri and postmenopausal women 2008-11-09 anticipated 100 Complete https://irct.ir/trial/832 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Hot flashes in peri and postmenopausal women. Intervention 1: placebo: 20 drops,three times daily for 2 months. Intervention 2: Hypiran: 20 drops, three times daily for 2 months.
public
scientific Khadijeh Abdali
Namazi sq.
Shiraz Iran (Islamic Republic of) +98 71164742547 abdalikh@sums.ac.ir Fatemeh College of nursing and midwifery Iran (Islamic Republic of) Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: (1) natural perimenopuse (3-11 months of amenorrhea or increased menstrual irregularity if still cycling) or postmenopause (12 or more months of amenorrhea) (2) untreated complaints for at least 2 months, (3) no history of cancer, (4) moderate to severe hot flashes happening at least once a day, (5) lack of illnesses creating hot flash-like symptoms, (6) presenting the serum level of FSH more than 40 mlu/ml. Exclusion criteria: (1) treatment with sexual hormones, nonhormonal climacteric drugs, or any treatment to alleviate climacteric symptoms in the last 12 weeks before study entry, (2) treatment with chemical or plant-derived medicines in the last 12 weeks before study entry, (3) bilateral oophorectomy, and (4) severe diseases (e.g., of the heart, liver, kidney, alimentary system, or metabolic diseases) or abnormal thyroid-stimulating hormone value that could mimic climacteric complaints or the actual or expected treatment or that could interfere with the study objectives. 45 years 60 years Female N95.1 Menopausal and female climacteric states Placebo Treatment - Drugs placebo: 20 drops,three times daily for 2 months Hypiran: 20 drops, three times daily for 2 months Decrease of the severity, frequency and duration of hot flashes. Timepoint: one month. Method of measurement: Kupperman Index. Deputy of Research of Shiraz University of Medical Sciences Approved The Medical Research Ethics Committee of Shiraz University of Medical Sciences Zand sq. Shiraz Iran (Islamic Republic of)