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IRCT20220119053762N2 IRCT 2025-06-18 Mashhad University of Medical Sciences Effect of propolis on surgical wound healing Investigating the effect of using bee propolis solution on the speed of surgical wound healing 2025-05-11 anticipated 10 Complete https://irct.ir/trial/83287 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: Given that both products used, i.e. placebo (normal saline) and propolis solution, are used in the same person, half of the wound is washed with one solution and half with the other. And the name of the containers containing the solution is coded. The patient is unaware of the allocation. Moreover, each person is his or her own control. And receives placebo and intervention simultaneously, all aspects of bias are eliminated. 2 Surgical wound. Intervention 1: In the patient, half of the surgical incision is considered as the intervention site. To avoid bias in horizontal incisions, the right side of the wound is considered as the intervention site, and in vertical incisions, the upper half of the wound is considered as the intervention site. The intervention site is washed twice daily with a 2% ethanol-based propolis solution. The intervention lasts for one week. Propolis will be supplied from Shahd Mom Pars Company. Intervention 2: Control group: In the present study, half of the surgical incision area was considered as the control site in each patient, such that in horizontal surgical incisions, the left side was considered as the control site and in vertical surgical incisions, the lower half was considered as the control site. The control group received routine care and treatment, which included intravenous antimicrobial treatment and dressing the site in case of discharge with normal saline solution manufactured by Samen Pharmaceutical Company (placebo), which was done daily for one week. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information.
public Aramesh Rezaeian
Azadi Square, Mashhad, Razavi Khorasan Province, Iran
Mashad Iran (Islamic Republic of) ٩١٧٧٩۴٩۰٢۵ +98 51 3882 9278 rezaeiana@mums.ac.ir Mashhad University of Medical Sciences scientific Aramesh Rezaeian
Azadi Square, Mashhad, Razavi Khorasan Province, Iran
Mashad Iran (Islamic Republic of) ٩١٧٧٩۴٩۰٢۵ +98 51 3882 9278 rezaeiana@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) 1- The surgery must have an incision, 2- The surgeon's consent to the patient's participation in the study, 3- Patient consent to participate in the study 4- The possibility of removing the operating room dressing on the second day after surgery, 5- Age over 18 years. 6- No history of allergy to bee products. 18 years no limit Both Treatment - Drugs Placebo In the patient, half of the surgical incision is considered as the intervention site. To avoid bias in horizontal incisions, the right side of the wound is considered as the intervention site, and in vertical incisions, the upper half of the wound is considered as the intervention site. The intervention site is washed twice daily with a 2% ethanol-based propolis solution. The intervention lasts for one week. Propolis will be supplied from Shahd Mom Pars Company. Control group: In the present study, half of the surgical incision area was considered as the control site in each patient, such that in horizontal surgical incisions, the left side was considered as the control site and in vertical surgical incisions, the lower half was considered as the control site. The control group received routine care and treatment, which included intravenous antimicrobial treatment and dressing the site in case of discharge with normal saline solution manufactured by Samen Pharmaceutical Company (placebo), which was done daily for one week. Speed ​​of wound healing. Timepoint: Before the intervention and then daily until the seventh day after the start of the intervention. Method of measurement: Taking pictures of the wound site. Mashhad University of Medical Sciences Approved 2025-04-12 Ethics Committee of Mashhad University of Medical Sciences Daneshgah Avenue, Mashad, Khoorasan Razavi , Iran Mashad Razavi Khorasan Iran (Islamic Republic of)