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IRCT20120520009801N15 IRCT 2025-06-08 Mashhad University of Medical Sciences Effect of rosehip on chronic coronary syndrome Investigating the Effect of Consuming Tablets Containing Rosehip Fruit Alcoholic Extract on Pain Severity in Patients with Chronic Coronary Syndrome 2025-06-22 anticipated 40 Complete https://irct.ir/trial/83667 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The method used to generate a random allocation sequence with a guarantee of equal allocation of individuals to the two groups is a permutation block created using the website www.randomization.com. With the explanation that each block has 4 members and the shape of the blocks is as follows: [AABB], [ABAB], [ABBA], [BABA], [BBAA], [BAAB] Code A belongs to the intervention group and code B belongs to the control group. Therefore, 12 quadruple blocks were randomly generated by the site and patients were assigned to two study groups based on the sequence obtained from the above blocks, Blinding description: The allocation concealment method is using opaque sealed envelopes with random sequences obtained from the random allocation step. The codes are given to the researcher present in the hospital. This researcher is fully aware of the type of codes. Medications are also given to him on the basis of the number (A or B) and he is fully aware of which drug or placebo. At the end of study, the evaluator (physician) who does not know which drug the patient has received and is aware only of the assigned code, performs the relevant evaluations and after registration, the results are given to the person who performs data analysis. 3 chronic coronary syndrome. Intervention 1: Intervention group: tablets containing 500 mg of hydroalcoholic extract of rose hip prepared in the pharmacognosy and pharmaceutical laboratory of Mashhad Faculty of Pharmacy, 2 tablets daily oral for 2 months. Intervention 2: Control group: Placebo tablets prepared in the pharmaceutical laboratory of the Mashhad Faculty of Pharmacy, 2 tablets daily oral for 2 months. Yes - There is a plan to make this available What will be shared: All data is potentially shareable after unidentifiable individuals When: starting 6 months after publication To whom: People working in academic institutions Conditions: The use of data is unimpeded by mentioning the source. Where to obtain: Dr. AmirHoushang Mohamadpour Mail: mohamadpoorah@mums.ac.ir Phone: 09153162909 How to obtain: Reply to email within a maximum of one week Comments:
public Amir Hooshang Mohammadpour
School of Pharmacy., Mashhad University of Medical Sciences
mashhad Iran (Islamic Republic of) 9177948954 +98 51 1882 3255 mohamadpoorah@mums.ac.ir Mashhad University of Medical Sciences scientific Amir Hooshang Mohammadpour
School of Pharmacy., Mashhad University of Medical Sciences
mashhad Iran (Islamic Republic of) 9177948954 +98 51 1882 3255 mohamadpoorah@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Diagnosis of Chronic Stable Angina Based on Clinical and Laboratory Parameters Obtaining Informed Consent from the Patient or Patient's Companion Absence of contraindications for exercise testing 18 years 75 years Both Conditions that may compromise the electrocardiogram (ECG) or exercise test interpretation Congestive heart failure functional class III or IV History of acute coronary syndrome Any method of coronary revascularization within two months of enrollment Pregnancy or breastfeeding Renal insufficiency (GFR < 60 ml/min) Liver failure (child pugh score B or C) I25.1 Atherosclerotic heart disease of native coronary artery Treatment - Drugs Treatment - Drugs Intervention group: tablets containing 500 mg of hydroalcoholic extract of rose hip prepared in the pharmacognosy and pharmaceutical laboratory of Mashhad Faculty of Pharmacy, 2 tablets daily oral for 2 months Control group: Placebo tablets prepared in the pharmaceutical laboratory of the Mashhad Faculty of Pharmacy, 2 tablets daily oral for 2 months Total duration of exercise test capacity. Timepoint: At baseline and two months after intervention. Method of measurement: Exercise test system. Time to onset of angina. Timepoint: At baseline and two months after intervention. Method of measurement: Exercise test system. Electrocardiographic changes. Timepoint: At baseline and two months after intervention. Method of measurement: Exercise test system. Double product. Timepoint: At baseline and two months after intervention. Method of measurement: Exercise test system. Duke score. Timepoint: At baseline and two months after intervention. Method of measurement: Exercise test system. Blood pressure. Timepoint: At baseline and two months after intervention. Method of measurement: Manometer. Heart rate. Timepoint: At baseline and two months after intervention. Method of measurement: Exercise test system. Lipid profile. Timepoint: At baseline and two months after intervention. Method of measurement: Blood test. Complete blood count(CBC). Timepoint: At baseline and two months after intervention. Method of measurement: Blood test. Fasting blood sugar. Timepoint: At baseline and two months after intervention. Method of measurement: Blood test. Liver function test. Timepoint: At baseline and two months after intervention. Method of measurement: Blood test. Kidney function profile. Timepoint: At baseline and two months after intervention. Method of measurement: Blood test. Mashhad University of Medical Sciences Approved 2025-04-26 Ethics committee of Mashhad University of Medical Sciences Vice Chancellor for Research and Technology, Third floor of Ghoreshi building, Next to Hoveyzeh Cinema, Daneshgah Street, Mashhad mashhad Razavi Khorasan Iran (Islamic Republic of)