IRCT201110317960N1 IRCT 2011-12-09 University of social welfare and rehabilitation sciences Efficacy of adjunctive topiramate in acute mania Comparison of efficacy of lithium and topiramate with lithium and placebo in patients with bipolar I disorder most recent manic episode 2011-07-30 anticipated 46 Complete https://irct.ir/trial/8392 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Condition 1: bipolar I disorder most recent manic episode. Condition 2: bipolar I disorder most recent manic episode. Intervention 1: In intervention group patients would receive 900mg/day of lithium carbonate and 2mg/day of risperidone (may be increased if needed to 8mg/day) or equivalent dose of other antipsychotics plus topiramate starting with 50 mg/day and increasing the dose 50 mg each 3 days to reach the maximum dose of 200 mg/day. Intervention 2: In control group patients would receive 900mg/day of lithium carbonate and 2mg/day of risperidone (may be increased if needed to 8mg/day) or equivalent dose of other antipsychotics plus placebo.