IRCT20120215009014N563 IRCT 2025-07-15 Hamedan University of Medical Sciences Effect of combined exercise (resistance exercise and high intensity interval training) versus control group on serum sirtuin 1 and 4 levels in men with non-alcoholic fatty liver disease Effect of combined exercise (resistance exercise and high intensity interval training) versus control group on serum sirtuin 1 and 4 levels in men with non-alcoholic fatty liver disease: a randomized clinical trial 2025-08-01 anticipated 30 Complete https://irct.ir/trial/84781 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random allocation of patients to intervention and control groups by lottery. For this purpose, we prepare two sheets, write "intervention" on one and "control" on the other. Then, with each patient's visit, one of the sheets is randomly taken and the patient is assigned to the intervention or control group. N/A Fatty liver. Intervention 1: Intervention group: Training and routine recommendations plus combined resistance exercise and high-intensity interval training (HIIT) for 45 to 60 minutes, 3 days a week, for 12 weeks include: training at an intensity of 70% of heart rate reserve or 84% of maximum heart rate during sprints of up to 30 seconds, in the first 6 weeks with a 5-minute warm-up on a treadmill, then 4 sets of 3 minutes with 3 minutes of rest between sets, and in the second 6 weeks, 5 sets of 3 minutes with 3 minutes of rest between sets. Intervention 2: Control group: Training and routine recommendations. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situation and the results of the study as well as the approval of the financial supporting organization.