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IRCT201111158098N2 IRCT 2012-01-11 Deputy for Research,Faculty of Medicine.Tabriz University of Medical Science Effect of Magnesium Sulfate on Diffuse Axonal Injury Efficacy of Magnesium Sulfate on the Clinical Course and GCS of Patients with Severe Diffuse Axonal Injury 2009-04-04 anticipated 38 Complete https://irct.ir/trial/8508 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. N/A brain trauma. Intervention 1: initial intravenous loading dose of 50mg/kg magnesium sulfate within one hour after trauma and then 50mg/kg every 6 hour magnesium sulfate up to 24 hours after trauma. Intervention 2: intravenous normal saline with the same dose of drug intervention.
public Yazdan Dokhte Gafari M
Tabriz University of Medical science, Faculty of Medicine
Tabriz Iran (Islamic Republic of) +98 41 1336 4667 y.dokhtegafary@yahoo.com Tabriz University of Medical Science scientific M.Shakeri
Emam Reza Hospital, Tabriz, Iran
Tabriz Iran (Islamic Republic of) +98 41 1336 4667 mshakeri@tbzmed.ac.ir Emam Reza Hospital Iran (Islamic Republic of) Inclusion criteria: Older than 18 and less than 65 years old; the time gap between trauma and admission to the medical center not exceeding more than one hour Exclusion criteria: renal failure; pregnancy; seizure; cardiac heart failure;cranial hematoma; intracranial surgery for hematoma; refractory systemic hemorrhage requiring blood product transfusion; intracranial hemorrhage 18 years 65 years Both S06.2 Diffuse brain injury Treatment - Drugs Placebo initial intravenous loading dose of 50mg/kg magnesium sulfate within one hour after trauma and then 50mg/kg every 6 hour magnesium sulfate up to 24 hours after trauma intravenous normal saline with the same dose of drug intervention Glascow coma scale (GCS). Timepoint: with in 2 month after trauma. Method of measurement: According to GCS score table. Motot function. Timepoint: 2 month after trauma. Method of measurement: according to evaluating muscle force. Adverse effect of magnesium sulfate. Timepoint: within 24 hours after magnesium sulfate administration. Method of measurement: yes or no. Deputy for Research,Faculty of Medicine.Tabriz University of Medical Science Approved 2010-08-03 Deputy for Research,Faculty of Medicine,Tabriz University of Medical Science Deputy for Research,Faculty of Medicine, Golgasht Ave. Tabriz.IR.IRAN Tabriz Iran (Islamic Republic of)