IRCT201111208140N1 IRCT 2012-03-05 Golestan University of Medical Sciences The effect of sodium and ultrafiltration profiles on preventing from the complications made during hemodialysis Combined effect of sodium and ultrafiltration profiles on some of the common complications during hemodialysis 2012-01-14 anticipated 44 Complete https://irct.ir/trial/8567 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Crossover, Purpose: Prevention. 3 End stage kidney disease. Intervention 1: For each group in this research, four different hemodialysis protocols are implemented. These protocols are as follows: Protocol 1: Linear Sodium Dialysate (150 - 138mEq/L) and constant Ultrafiltration. Protocol 2: Constant Sodium Dialysate (140 mEq/L) and gradient ultrafiltration. Protocol 3: Linear Sodium Dialysate (150 - 138 mEq/L) and gradient ultrafiltration. Protocol 4: (standard hemodialysis) = Constant Sodium Dialysate (140 mEq/L) and constant Ultrafiltration. Linear Sodium Dialysate: In the first hour of the dialysis the amount of Sodium dialysate is 150mEq/L, then is gradually decreasing by 4mEq/L per hour. In the last hour of the dialysis, it reaches 138mEq/L. Gradient Ultrafiltration: Two-thirds of the fluid acquired between 2 dialysis sessions is removed during the first two hours of the dialysis and the reset in the last two hours. This protocol can be programmed on Gambro AK96 dialysis machine. Constant Ultrafiltration: The excessive fluid acquired between hemodialysis is determined. This fluid is taken back in equal volumes in each hour of a four -hour dialysis session. Constant Sodium Dialysate: During a four -hour -dialysis session, sodium dialysate is kept in140 mEq/L. For any patients, six hemodialysis sessions are considered for each of the protocols. For group A, protocols, 1-2-3 and 4 run respectively. Intervention 2: For Group B, protocols, 2-3-4 and 1 run respectively. Intervention 3: For Group C, protocols, 3-4-1 and 2 run respectively. Intervention 4: For Group D, protocols, 4-1-2 and 3 run respectively.