IRCT20220322054341N3 IRCT 2025-10-22 Iran University of Medical Sciences The effect of svf in periorbital rejuvenation Investigating the effect of stromal vascular fraction gel (svf+non cross-linked hyaluronic acid)on the periorbital rejuvenation and comparig it with svf injection alone 2025-09-22 anticipated 10 Complete https://irct.ir/trial/86768 interventional Randomization: N/A, Blinding: Double blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment, Blinding description: The injection of stromal vascular fraction (SVF), stromal vascular fraction (SVF)and normal saline was done with syringes of the same shape, the contents of which are not known, and the patient does not know which treatment group he is in. Also, the doctor evaluating the results and the statistician are blinded to the treatment group of the patient. N/A periorbital aging/wrinkles/hyperpigmentation. Intervention 1: Intervention group: Intervention Group 1: Injection of 2 cc stromal vascular fraction (SVF) cells extracted from abdominal fat into one side of the periocular area. Fat harvesting involves 40 cc abdominal fat aspiration, followed by centrifugation at 1200g for 3 minutes, nanofat separation with physical filters, and a second centrifugation at 2000g for 3 minutes to isolate the SVF layer. Injection is intradermal, at 1 cm intervals, in a single session. Intervention 2: .Intervention Group 2: Injection of a combination of 1 cc SVF (prepared as above) and 1 cc non-crosslinked hyaluronic acid gel (Luxiva) into the contralateral periocular area. The mixture is injected intradermally at 1 cm intervals, in a single session.Both interventions are randomly assigned to either the left or right side. Patients and evaluators (two dermatologists) are blinded to the type of injection on each side (double-blind. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is نامشخص