IRCT20250824066979N1 IRCT 2026-07-07 Islamic Azad University Comparison of the efficacy of Vonoprazan with omeprazole in the quadruple therapy of Helicobacter pylori infection Comparison of the efficacy of Vonoprazan with omeprazole in the quadruple therapy of Helicobacter pylori infection 2026-07-23 anticipated 150 Recruiting https://irct.ir/trial/87093 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The randomization technique employed in this study is the block method. In this process, patients are first divided into groups of four. Next, blocks representing four different arrangements of groups A and B are defined—specifically AABB, ABAB, ABBA, BBAA, BABA, and BAAB—resulting in a total of six block types. Subsequently, Microsoft Excel is used to generate random numbers corresponding to the number of groups; the groups are then sorted based on these numbers (in ascending order) and assigned to the designated blocks. Finally, the patients previously assigned to each group are allocated to one of the intervention groups (A or B) according to the sequence established within their respective blocks. Finally, using the numbered-envelope technique, groups A and B are assigned to either the intervention or the control group. In this way, patients are randomly distributed in equal numbers between the two study groups; Group A is designated as the intervention group, and Group B as the control group, Blinding description: In this study, a double-blind design will be used. Both the participants and the principal investigators will be completely blinded to the assignment of the study groups (study treatment or routine treatment). This will be achieved by preparing the study drug and the routine drug coded with a unique serial number, without disclosure of the drug type. The manuscript authors will remain blinded to the identity of the groups until the completion of recruitment, database lock, and the initial analysis. 3 بیماری هلیکوباکتری پیلوری. Intervention 1: Intervention group: Patients presenting with symptoms of dyspepsia or epigastric pain and a positive endoscopic biopsy undergo a 14-day treatment regimen consisting of bismuth (300 mg four times daily), vonoprazan (20 mg twice daily), amoxicillin (1000 mg twice daily), and clarithromycin (500 mg twice daily); they are subsequently evaluated for eradication using a stool antigen test one month after the completion of treatment. Intervention 2: Control group: Patients presenting with symptoms of dyspepsia or epigastric pain and a positive endoscopic biopsy undergo a 14-day treatment regimen consisting of bismuth (300 mg four times daily), omeprazole (20 mg twice daily), amoxicillin (1000 mg twice daily), and clarithromycin (500 mg twice daily); they are subsequently evaluated for eradication using a stool antigen test one month after the completion of treatment. No - There is not a plan to make this available Justification or reason for not sharing IPD is No further information available