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IRCT201307188300N2 IRCT 2013-11-05 Shiraz University of Medical Sciences Evaluation of the effect of green tea extracts in osteoarthritis Evaluation of the effect of green tea extracts in patients with mild to moderate knee osteoarthritis 2012-12-21 anticipated 40 Complete https://irct.ir/trial/8725 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Osteoarthritis. Intervention 1: cases received 1500 mg/day of green tea leaves in 3 doses(Dineh Company with certification number:1228144011) plus 100 mg/day diclofenac. Intervention 2: control group: 100 mg Diclofenac.
public Sara Sadrneshin
School of Medicine
Shiraz Iran (Islamic Republic of) +98 71 1234 1979 sarah_sadrneshin@yahoo.com Shiraz University of Medical Sciences scientific Alireza Ashraf
Shiraz University of Medical Sciences - Department of Physical Medicine and Rehabilitation
Shiraz Iran (Islamic Republic of) +98 71 1231 9040 alirezaashraf@yahoo.com; sadrneshin@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients of both sexes with mild to moderate osteoarthritis of the knee, in the age group 40 to 75 years, referred to the Physical Medicine and Rehabilitation, Shiraz, Iran. Exclusion criteria: patients with severe osteoarthritis; patients suffering ischemic heart disease or heart failure; patients with renal function impairment; patients with hepatic failure; pregnant women; breastfeeding women; women who stop contraception techniques to become pregnant; patients who had a history of sensitivity to caffeine; patients whose diets are effective for weight loss or gain, and planned to decrease or increase their weight; patients who have recently begun the exercise to protect joints or changing their activity levels; patients treated with alkaline agents, for any reason, who was not able to discontinue their medications; patients treated with warfarin for any reason, that the patient was unable to stop his warfarin; patients with a history of gastrointestinal bleeding with non-steroidal anti-inflammatory drugs; patients who for any reason were not able to express their pain (eg patients with mental retardation or patients with Alzheimer's); patients who did not receive the necessary support for their drugs or they are not likely to be followed (eg, patients who were residents of older people centers ); patients who do not continure the trial: intolerable side effects for the patient (Gastrointestinal side effects such as increased gastric acid secretion, diarrhea or constipation, headache, palpitations, insomnia, irritability, restlessness);discontinuation of drugs consumption for any reason and not to follow treatment for any reason. 40 years 75 years Both M17.0 Primary gonarthrosis, bilateral Treatment - Drugs Treatment - Drugs cases received 1500 mg/day of green tea leaves in 3 doses(Dineh Company with certification number:1228144011) plus 100 mg/day diclofenac control group: 100 mg Diclofenac Function. Timepoint: at the beginning and 1 month after intervention. Method of measurement: WOMAC quastionaire. Pain. Timepoint: at the beginning and 1 month after intervention. Method of measurement: WOMAC quastionaire. Joint stiffness. Timepoint: at the beginning and 1 month after intervention. Method of measurement: WOMAC quastionaire. Shiraz University of Medical Sciences Approved 2010-09-23 Shiraz university of medical science Shiraz University of Medical Sciences Shiraz Iran (Islamic Republic of)