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IRCT20120129008863N13 IRCT 2025-11-17 Research assistant of University of Kurdistan Comparison of the Efficacy of 12 Weeks of Combined Training with and Without Taurine Supplementation on the Control of adipokines Indices in obese men Comparison of the Efficacy of 12 Weeks of Combined Training with and Without Taurine Supplementation on the Control of adipokines Indices in obese men 2025-11-21 anticipated 44 Complete https://irct.ir/trial/87436 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Health service research, Randomization description: This study will utilize a simple randomization method. Participants will be randomly divided into four groups: an intervention group receiving combined exercise with taurine supplementation (n=11), an exercise group with a placebo (n=11), a taurine supplementation-only group (n=11), and a placebo-only group (n=11). The randomization will be conducted at the individual level, whereby each of the 44 participating individuals will be assigned to one of the four groups. A computerized sequence will be used to randomly allocate participants to each group. This method ensures high accuracy and reproducibility and minimizes selection bias.The participant allocation sequence was generated using the Block Randomization method. Variable block sizes (e.g., 4 and 8) and a 1:1:1:1 allocation ratio were implemented to ensure a balanced distribution of participants across the four groups. This random sequence was produced by a reliable statistical software or a dedicated computer program. Specifically, the specialized statistical software SPSS version 26 was utilized to generate the allocation sequence, Blinding description: The present study is a single-blind clinical trial. The single-blinding applies to the taurine and placebo consumption. Participants will read the research protocol during the first session. The supplement and placebo are contained in identical capsules. The capsules will be distributed among the participants. Only the researcher is aware of the contents of the capsules. N/A Overweight and obesity. Intervention 1: Intervention group:Exercise and Taurine GroupThis group consumes an oral capsule in three $1 \text{g}$ doses (after breakfast, lunch, and dinner) daily for 12 weeks. The Taurine supplement is provided by the pharmaceutical company Cayman Chemical, USA. The combined exercise regimen includes: Interval Training: Intensity progressively increases from 50-55% to 70-75% of the HRmax. Resistance Training: Performed at an intensity equivalent to 60% of one-repetition maximum (1RM) for 12 weeks, consisting of 3 sessions per week, with each session lasting 15 to 25 minutes. Intervention 2: Intervention group: Exercise and Placebo Group: This group consumes a starch oral capsule in three 1 g doses (after breakfast, lunch, and dinner) daily for 12 weeks. The combined exercise regimen includes: Interval Training: Intensity progressively increases from 50-55% to 70-75% of the HRmax. Resistance Training: Performed at an intensity equivalent to 60% of 1RM for 12 weeks, consisting of 3 sessions per week, with each session lasting 15 to 25 minutes. Intervention 3: Intervention group: Taurine Group: This group consumes an oral capsule in three 1 g doses (after breakfast, lunch, and dinner) daily for 12 weeks. Intervention 4: Control group: Placebo Group: This group consumes a starch oral capsule in three 1 g doses (after breakfast, lunch, and dinner) daily for 12 weeks. Yes - There is a plan to make this available What will be shared: All data, including the IPD, study protocol, statistical analysis map, informed consent form, clinical study report, and data dictionary, will be published upon completion of the study. This data will be made available in a valid journal article format. When: Data will be accessible immediately upon project completion, likely in 1405 To whom: This is intended for researchers at academic and scientific Conditions: Institutions to support the development of related sciences. Where to obtain: Refer to University of Kurdistan How to obtain: Please submit a valid letter from the scientific centers. Comments:
public Ayoub Saeidi
Iran, Sanandaj, Pasdaran Boulevard, University of Kurdistan
Sanandaj Iran (Islamic Republic of) 6617715175 +98 87 3366 4600 a.saeidi@uok.ac.ir University of Kurdistan scientific Ayoub Saeidi
Iran, Sanandaj, Pasdaran Boulevard, University of Kurdistan
Sanandaj Iran (Islamic Republic of) 6617715175 +98 87 3366 4600 a.saeidi@uok.ac.ir University of Kurdistan Iran (Islamic Republic of) Inactive Female, aged 23 to 32 In good general physical and mental health Body mass index greater than 30 kg/m² 23 years 32 years Male Any physical injury or orthopedic issue that interferes with training can hinder its quality E66 Overweight and obesity Rehabilitation Rehabilitation Rehabilitation Rehabilitation Intervention group:Exercise and Taurine GroupThis group consumes an oral capsule in three $1 \text{g}$ doses (after breakfast, lunch, and dinner) daily for 12 weeks. The Taurine supplement is provided by the pharmaceutical company Cayman Chemical, USA. The combined exercise regimen includes: Interval Training: Intensity progressively increases from 50-55% to 70-75% of the HRmax. Resistance Training: Performed at an intensity equivalent to 60% of one-repetition maximum (1RM) for 12 weeks, consisting of 3 sessions per week, with each session lasting 15 to 25 minutes. Intervention group: Exercise and Placebo Group: This group consumes a starch oral capsule in three 1 g doses (after breakfast, lunch, and dinner) daily for 12 weeks. The combined exercise regimen includes: Interval Training: Intensity progressively increases from 50-55% to 70-75% of the HRmax. Resistance Training: Performed at an intensity equivalent to 60% of 1RM for 12 weeks, consisting of 3 sessions per week, with each session lasting 15 to 25 minutes. Intervention group: Taurine Group: This group consumes an oral capsule in three 1 g doses (after breakfast, lunch, and dinner) daily for 12 weeks. Control group: Placebo Group: This group consumes a starch oral capsule in three 1 g doses (after breakfast, lunch, and dinner) daily for 12 weeks. Spexin. Timepoint: Before the intervention and three months following it. Method of measurement: zellBio kit (mmol/l). Asprosin. Timepoint: Before the intervention and three months following it. Method of measurement: zellBio kit (mmol/l). Body Mass Index (BMI) Kg/m2. Timepoint: Before the intervention and three months following it. Method of measurement: The body mass (kg) divided by the square of the body height (cm). Research assistant of University of Kurdistan Approved 2025-10-25 Hakim Sabzevari University Hakim Sabzevari University, Tohid Shahr, Sabzevar; Department of Sport Sciences Sabzevar Razavi Khorasan Iran (Islamic Republic of)