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IRCT20141209020258N201 IRCT 2025-11-17 Arak University of Medical Sciences Comparison of the effects of ginger and dexamethasone and ondansetron and promethazine in reducing postoperative nausea and vomiting in patients undergoing hysterectomy Comparison of the effects of ginger and dexamethasone and ondansetron and promethazine in reducing postoperative nausea and vomiting in patients undergoing hysterectomy 2025-11-22 anticipated 100 Recruiting https://irct.ir/trial/87536 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be allocated into4 groups using a permuted balanced block randomization method with the size of blocks8. Random sequence will be generated by an epidemiologist by running an online program in sealed envelope website (https://www.sealedenvelope.com/). Random chain concealment is done by opaque envelope method, Blinding description: The study is double-blind. The analysis is done by the analyst and outcome evaluator (double-blind) and the participant. The analyst, evaluator, and participant are unaware of the consequences of grouping. The patients under study, as well as all project staff, including surgeons, anesthesia technicians, scrub nurses, and interns, will be unaware of how patients are assigned to the groups. 2-3 Hysterectomy. Intervention 1: Intervention group1: Patients in the ginger group receive two 500 mg Vomegan Dineh ginger tablets (manufactured by Dineh Bern Company), each containing 500 mg of ginger, one hour before the surgery. To standardize the appearance of the received medications, they also receive 4 ml of distilled water in a serum. Intervention 2: Intervention group2: Patients in the ondansetron group receive 8 mg of ondansetron (manufactured by Alborz Darou Pharmaceutical Company). Intervention 3: Intervention group3: Patients receive 8 mg of dexamethasone (manufactured by Alborz Darou Pharmaceutical Company) intravenously before anesthesia induction.Promethazine Group:. Intervention 4: Intervention group4: Patients receive 6.25 mg of promethazine (manufactured by Alborz Darou Pharmaceutical Company) intravenously before anesthesia induction. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Dr Hesamedin Modir
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 modir.he@gmail.com Arak University of Medical Sciences scientific Dr Alireza Kamali
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 68 3222 2003 alikamaliir@yahoo.com Arak University of Medical Sciences Iran (Islamic Republic of) No history of cancer No history of high blood pressure Age between 40 to 60 years Ability to swallow the pill used in the study Platelet count above 100000, no history of intestinal obstruction and hepatitis No use of anti-nausea and anti-vomiting drugs or drugs that induce them No history of allergy to ginger No use of blood-thinning and anticoagulant drugs before surgery 40 years 60 years Both Lack of patient's consent to participate in the study Willingness to cooperate Patients who experience cardiopulmonary arrest during surgery Patients who are referred to the intensive care unit for any reason N99.3 Prolapse of vaginal vault after hysterectomy Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group1: Patients in the ginger group receive two 500 mg Vomegan Dineh ginger tablets (manufactured by Dineh Bern Company), each containing 500 mg of ginger, one hour before the surgery. To standardize the appearance of the received medications, they also receive 4 ml of distilled water in a serum. Intervention group2: Patients in the ondansetron group receive 8 mg of ondansetron (manufactured by Alborz Darou Pharmaceutical Company). Intervention group3: Patients receive 8 mg of dexamethasone (manufactured by Alborz Darou Pharmaceutical Company) intravenously before anesthesia induction.Promethazine Group: Intervention group4: Patients receive 6.25 mg of promethazine (manufactured by Alborz Darou Pharmaceutical Company) intravenously before anesthesia induction. Incidence of nausea. Timepoint: Recovery and 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Observation. Vomiting. Timepoint: Recovery and 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Score 0 to 4. Sedation. Timepoint: In recovery and 1, 2 and 4 hours after surgery. Method of measurement: Ramsay score. Arak University of Medical Sciences Approved 2025-10-19 Ethics comittee of Arak University of Medical Sciences Ethics comittee, Research center, Payambar Azam complex, Basij squre ,Sardasht,Arak Arak Markazi Iran (Islamic Republic of)