IRCT201405208315N7 IRCT 2014-08-25 Tabriz University of Medical Sciences The effect of physical activity on Physiological and Behavioral Responses, Motor performance and Neuro-mascular Development Comparison the effect of Physical Activity Programs on Physiological and Behavioral Responses, Motor Performance and Neuromuscular Development in preterm Infants: Single blind Randomized Clinical Trial 2014-08-16 anticipated 72 Complete https://irct.ir/trial/8765 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. N/A 1-Preterm Infant 2- low birth weight. Intervention 1: 1-The physical activity program wil be based on the Moyer-Mileur protocol. Then repetitions of each movement were performed on the Wrists, Elbows, Shoulders, Ankles, Knees and Hips joints. The sequence was performed slowly and in the cephalocaudal direction, with an average of six movements per min, and in the following sequence: right arm, left arm, right leg, left leg and, finally, simultaneous movements on both legs.¬ Intervention will be done for a total of 15 min. 2- Hydrotherapy activity will be done semi-circular movements in the pelvic area while the head and neck will constant and then semi-circular motions will performed in the head and neck while the pelvis will be constant. Intervention will be done for a total of 10 min. 3- Containment include putting the infant in fetal position (feet gathered on the abdomen and head bent the chest). Baby will be hold Daily once for 15 minutes. Intervention 2: Holding group’s :The researcher will be kept baby in fetal position to support the head¬, neck and extremities (the bent in the midline) for 15 min, once daily. Intervention 3: Hydrotherapy groups: semi rotational movements of the head and neck will be doing while pelvic area is constant and then semi rotational movements of the pelvic will be doing while the head and upper parts are constant , it will run during 10 minutes.