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IRCT201107311556N28 IRCT 2011-07-31 Erphan Teb Turmeric in the treatment of recurrent aphthous stomatitis Turmeric trial Turmeric in the treatment of recurrent aphthous stomatitis: a double blind and placebo controlled trial 2011-07-31 anticipated 50 Complete https://irct.ir/trial/878 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Recurrent aphthous stomatitis. Intervention 1: Intervention group: Turmeric Jel (topical) three time a day by a swap. Intervention 2: Control group: Placebo gel, three time a day (topical) by a swap.
public
scientific Shahin Akhondzadeh
Psychiatric Research Center, Roozbeh Hospital
Tehran Iran (Islamic Republic of) +98 21 6641 8466 S.akhond@sina.tums.ac.ir Tehtan University of Medical Sciences Iran (Islamic Republic of) 50 Patients between 20 and 45 years old will be included if they present with 1–5 aphthous ulcers of less than 24 h duration. The ulcers diameter will not be greater than 6 mm and they do not suffer from acute or chronic diseases of the oral mucosa Patients will be excluded from the study if they have concurrent clinical conditions including serious liver, kidney, and heart dysfunctions or if they have ulcers as a manifestation of a systemic disease process such as ulcerative colitis, Crohn’s disease, Behcet’s syndrome, or serious anaemia. To minimize the effect of confounding variables in the psycho- physiological component of the study, the patients should not have a history of alcohol or drug abuse and should not take any narcotic analgesics. Patients will be excluded if they have a history of systemic immunosuppressive therapy. 20 years 45 years Both K 12.0 Recurrent oral aphthae Treatment - Drugs Placebo Intervention group: Turmeric Jel (topical) three time a day by a swap Control group: Placebo gel, three time a day (topical) by a swap Decrease of pain. Timepoint: Before treatment and days 2, 4, 6, 10 and 14 after treatment. Method of measurement: VAS rating scale. Size of ulcers. Timepoint: Before drug application (day 0) and at days 2, 6, 10 and 14. Method of measurement: Diameters. Erphan Teb Approved 2011-04-21 Tehran University of Medical Sciences Keshavarz Blvd Tehran Iran (Islamic Republic of)