IRCT20251121068066N6 IRCT 2025-12-27 Yasouj University of Medical Sciences Comparison of the effect of intravenous caffeine, dexamethasone and aminophylline injection on headache after spinal anesthesia in patients undergoing section surgery Comparison of the effect of intravenous caffeine, dexamethasone and aminophylline injection on headache after spinal anesthesia in patients undergoing section surgery 2025-05-22 anticipated 140 Complete https://irct.ir/trial/87900 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Randomization was performed using block randomization to ensure balanced allocation across the four study groups. After obtaining written informed consent at the entrance to the operating room, eligible patients were randomly assigned to one of the four groups (control/placebo, caffeine, dexamethasone, or aminophylline). Fixed blocks of four were used, with each group appearing once in each block. The allocation order within each block was determined using a random number table, and this process continued until equal group sizes (35 participants per group) were achieved. 2 Headache. Intervention 1: Intervention group: Caffeine Group: Participants receive intravenous caffeine at a dose of 500 mg diluted in 500 mL normal saline, administered immediately after delivery and placental separation. A second dose is administered 12 hours later. Patients are monitored for potential adverse effects, including tachycardia and cardiac arrhythmias. Intervention 2: Intervention group: Dexamethasone Group: Participants receive a single intravenous dose of 8 mg dexamethasone immediately after delivery and placental separation. Intervention 3: Intervention group: Aminophylline Group:Participants receive intravenous aminophylline at a dose of 0.4 mg/kg/hour, initiated immediately after delivery and placental separation. Intervention 4: Control group: Participants receive a placebo consisting of distilled water administered intravenously immediately after delivery of the newborn and placental separation. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No further information available.