<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT20221024056281N2</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2025-12-20</date_registration>
      <primary_sponsor>Karaj University of Medical Sciences</primary_sponsor>
      <public_title>“Comparison of Two Psychological Approaches in Reducing Mental Pain and Feelings of Dissociation in University Students”</public_title>
      <acronym></acronym>
      <scientific_title>Comparing the effectiveness of integrated transdiagnostic therapy and acceptance and commitment therapy based on compassion on mental pain and the experience of dissociation in medical students with suicidal thoughts</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2025-12-20</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>60</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/87923</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: The sample from the initial selection was allocated into three groups by simple randomization.</study_design>
      <phase>2</phase>
      <hc_freetext>Suicide.</hc_freetext>
      <i_freetext>Intervention 1: Intervention Group 1: Integrated Transdiagnostic Therapy (20 participants, eight 90-minute sessions)First session: Increasing motivation, motivational interviewing for participant participation and engagement during treatment, presenting the rationale for treatment and determining treatment goalsSecond session: Recognizing emotion, providing psychological education on the adaptive and functional nature of emotions, and teaching the three-component model of emotional experiencesThird session: Recognizing and tracking emotional experiences, monitoring emotional experiences, introducing ARC emotions, introducing learned emotional response concepts.Fourth session: Teaching arousal, observing experiences, illicit emotional feelings, getting to know the present, performing emotional exercises, training techniques using mood inductionFifth session: Cognitive assessment and reappraisal, introducing thought traps, introducing cognitive assessment, practicing ambiguous imagery, changing cognitive assessmentSixth session: Emotion and types of emotional strategies, how emotions affect emotional experiences, examining and identifying different strategies for thinking about emotion.Seventh session: Emotional behaviors; About exciting behaviors, how EDB affects emotional experiences, identifying and responding to EDBsSession eighth: Understanding physical and possible feelings with, symptom induction test, repeated presence and post-test administration, termination of treatment. Intervention 2: Intervention Group 2: Compassion-Based Acceptance and Commitment Therapy (20 participants, eight 90-minute sessions)First, the goal and content: introducing therapy sessions, conducting a pre-test, introducing and getting to know the group members, stating the group rules and goals, introducing acceptance and commitment therapy based on compassion, suffering, healing, and introducing the causes of human suffering. Homework: Doing self-practice, presenting an assignment to examine behaviors based on self typesSecond goal and content: Efficacy as a measurement criterion, creating creative frustration, introducing emotion regulation systems, introducing types of human suffering, introducing types of human needs, introducing dimensions of compassionThird goal and content: Feedback from the previous session, summarizing past sessions, expressing control as a problem (problem), the conscious brainHomework: Reviewing last week's assignment, presenting the assignment sheet and then reviewing it based on compassionate reasoningFourth goal and content: Using cognitive fault-finding techniques, intervening in the functioning of problematic language chains, weakening good alliances with thoughts and emotionsHomework: Feedback from the previous session, reviewing the assignment from the previous session, presenting the assignment sheet to look mindfully at feelings and stay with feelings, reviewing the assignment and behavioral commitment, practicing receiving kindness from colleagues, performing the assignment to be kind to colleagues, performing the role-playing exercise of being kind to oneselfFifth goal and content: Providing a summary of previous sessions, reviewing the assignments from the previous session, getting feedback from the process of the sessions, weakening the self-concept and expressing oneself as an observer, demonstrating separation between selves, inner experiences and behavior, application of mindfulness techniques, performing imagery, introducing the characteristics of a kind personPresentation of homework: homework sheet including mindfully looking at suffering, compassionate reasoning towards suffering, mindfully seeing emotions and performing imagery while sufferingSixth goal and content: Providing a summary of previous sessions, getting feedback from the session process, modeling exiting the mind, learning to see inner experiences as a process, introducing different dimensions of compassionate attention, introducing non-judgmentalismAssignment: Reviewing the assignments of the previous session, presenting the assignment of listing the positive and negative values of oneself and colleagues and practicing paying attention instead of being drySeventh goal and content of the session: Showing the dangers of focusing on results, discovering practical values in life, retelling the characteristics of a kind person, introducing compassionate behavior, introducing types of compassionate behavior. Assignment: Feedback from the previous session, summary of previous sessions, presenting the assignment of practicing types of compassionate behaviors in everyday behaviors, practicing behaviors one by one at firstEighth goal and content of the session: Determining patterns of action consistent with values, re-introducing compassionate behavior. Assignment: Feedback from the previous session, review of last week's assignment, case-by-case review of behaviors based on the training provided in previous sessions. Intervention 3: Control Group: No intervention (20 participants).</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan>No - There is not a plan to make this available</results_IPD_plan>
      <results_IPD_description>Justification or reason for not sharing IPD is Due to confidentiality</results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>hedieh babakhanzadeh</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Mansour Bakht St., Imam Hussein Hospital, Imam Khomeini Blvd., Mohammad Shahr, Karaj</address>
        <city>alborz</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>3184669519</zip>
        <telephone>+98 26 3419 3000</telephone>
        <email>hedieh.khanzadeh@yahoo.com</email>
        <affiliation>Karaj University of Medical Sciences</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>hedieh.khanzadeh</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Mansour Bakht St., Imam Hussein Hospital, Imam Khomeini Blvd., Mohammad Shahr, Karaj</address>
        <city>alborz</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>3184669519</zip>
        <telephone>+98 26 3419 3000</telephone>
        <email>hedieh.khanzadeh@yahoo.com</email>
        <affiliation>Karaj University of Medical Sciences</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Iran (Islamic Republic of)</country2>
    </countries>
    <criteria>
      <inclusion_criteria>Studying in one of the medical sciences fields of the University of Medical Sciences
Age between 18 and 35 years
Consent to participate in the study
Having suicidal thoughts based on the cut-off score of the Beck Suicidal Thoughts Questionnaire before randomization</inclusion_criteria>
      <agemin>18 years</agemin>
      <agemax>35 years</agemax>
      <gender>Both</gender>
      <exclusion_criteria>Not using antipsychotic medications
Withdrawing from the study
Missing three or more intervention sessions
Having a mental illness or disorder</exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code></hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword></hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Prevention</i_code>
      <i_code>Prevention</i_code>
      <i_code>Prevention</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>Intervention Group 1: Integrated Transdiagnostic Therapy (20 participants, eight 90-minute sessions)First session: Increasing motivation, motivational interviewing for participant participation and engagement during treatment, presenting the rationale for treatment and determining treatment goalsSecond session: Recognizing emotion, providing psychological education on the adaptive and functional nature of emotions, and teaching the three-component model of emotional experiencesThird session: Recognizing and tracking emotional experiences, monitoring emotional experiences, introducing ARC emotions, introducing learned emotional response concepts.Fourth session: Teaching arousal, observing experiences, illicit emotional feelings, getting to know the present, performing emotional exercises, training techniques using mood inductionFifth session: Cognitive assessment and reappraisal, introducing thought traps, introducing cognitive assessment, practicing ambiguous imagery, changing cognitive assessmentSixth session: Emotion and types of emotional strategies, how emotions affect emotional experiences, examining and identifying different strategies for thinking about emotion.Seventh session: Emotional behaviors; About exciting behaviors, how EDB affects emotional experiences, identifying and responding to EDBsSession eighth: Understanding physical and possible feelings with, symptom induction test, repeated presence and post-test administration, termination of treatment.</i_keyword>
      <i_keyword>Intervention Group 2: Compassion-Based Acceptance and Commitment Therapy (20 participants, eight 90-minute sessions)First, the goal and content: introducing therapy sessions, conducting a pre-test, introducing and getting to know the group members, stating the group rules and goals, introducing acceptance and commitment therapy based on compassion, suffering, healing, and introducing the causes of human suffering. Homework: Doing self-practice, presenting an assignment to examine behaviors based on self typesSecond goal and content: Efficacy as a measurement criterion, creating creative frustration, introducing emotion regulation systems, introducing types of human suffering, introducing types of human needs, introducing dimensions of compassionThird goal and content: Feedback from the previous session, summarizing past sessions, expressing control as a problem (problem), the conscious brainHomework: Reviewing last week's assignment, presenting the assignment sheet and then reviewing it based on compassionate reasoningFourth goal and content: Using cognitive fault-finding techniques, intervening in the functioning of problematic language chains, weakening good alliances with thoughts and emotionsHomework: Feedback from the previous session, reviewing the assignment from the previous session, presenting the assignment sheet to look mindfully at feelings and stay with feelings, reviewing the assignment and behavioral commitment, practicing receiving kindness from colleagues, performing the assignment to be kind to colleagues, performing the role-playing exercise of being kind to oneselfFifth goal and content: Providing a summary of previous sessions, reviewing the assignments from the previous session, getting feedback from the process of the sessions, weakening the self-concept and expressing oneself as an observer, demonstrating separation between selves, inner experiences and behavior, application of mindfulness techniques, performing imagery, introducing the characteristics of a kind personPresentation of homework: homework sheet including mindfully looking at suffering, compassionate reasoning towards suffering, mindfully seeing emotions and performing imagery while sufferingSixth goal and content: Providing a summary of previous sessions, getting feedback from the session process, modeling exiting the mind, learning to see inner experiences as a process, introducing different dimensions of compassionate attention, introducing non-judgmentalismAssignment: Reviewing the assignments of the previous session, presenting the assignment of listing the positive and negative values of oneself and colleagues and practicing paying attention instead of being drySeventh goal and content of the session: Showing the dangers of focusing on results, discovering practical values in life, retelling the characteristics of a kind person, introducing compassionate behavior, introducing types of compassionate behavior. Assignment: Feedback from the previous session, summary of previous sessions, presenting the assignment of practicing types of compassionate behaviors in everyday behaviors, practicing behaviors one by one at firstEighth goal and content of the session: Determining patterns of action consistent with values, re-introducing compassionate behavior. Assignment: Feedback from the previous session, review of last week's assignment, case-by-case review of behaviors based on the training provided in previous sessions.</i_keyword>
      <i_keyword>Control Group: No intervention (20 participants)</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>Mental pain and the experience of disconnection. Timepoint: Pre-test: Before the start of the intervention - Post-test: After the end of 8 intervention sessions - Follow-up: One month after the intervention. Method of measurement: Beck Suicidal Ideation Scale - Auerbach and Mikulinser Mental Pain Questionnaire - Dissociation Experience Scale.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome></sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>Karaj University of Medical Sciences</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2025-09-23</approval_date>
        <contact_name>Ethics Committee of Alborz University of Medical Sciences</contact_name>
        <contact_address>Imam Hossein Educational and Medical Center, Mohammadshahr, Karaj, Alborz karaj Alborz Iran (Islamic Republic of)</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
