IRCT20250105064277N2 IRCT 2026-04-22 Shahre-kord University of Medical Sciences Comparison of two solutions used during hydatid cyst surgery to prevent disease recurrence - Comparison of chlorhexidine gluconate 0.04% with hypertonic saline as a scolcidal agent during liver hydatid surgery and the recurrence of hydatid cyst 2026-04-30 anticipated 40 Recruiting https://irct.ir/trial/88448 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: This randomized clinical trial employs balanced block randomization with an allocation ratio of 1:1 to assign eligible patients into two intervention groups. Block randomization is used to ensure balanced group sizes throughout the recruitment period. Variable block sizes (e.g., 4 and 6) are generated randomly to prevent predictability of treatment allocation. The exact block sizes are not disclosed to the research team to minimize selection bias, Blinding description: A double-blind design is implemented in this study. Blinding is maintained as follows: 1. Participants: Patients are unaware of which scolicidal solution is used during surgery. Both solutions are presented in identical, unlabeled packages. 2. Surgeons and Clinical Staff: The operating surgeon and clinical team performing patient care are blinded to group allocation. Intervention packages are prepared by an independent supervisor and identified only by coded 1 and 2 labels. 3. Data Collectors and Outcome Assessors: Data collection, form completion, and outcome evaluation (including CT scan assessment for recurrence) are performed by investigators who remain blinded to treatment allocation. 4. Data Analysts: Statistical analyses are conducted using coded group labels (Group 1 and Group 2), without revealing the actual intervention identity. 5. Study Supervisor: Only the study supervisor has access to the allocation code and does not participate in patient recruitment, treatment, data collection, or data analysis. Thus, blinding is preserved from patient enrollment through intervention delivery, outcome assessment, and statistical analysis. 3 Hepatic hydatid cyst; Liver echinococcosis; Hydatid cyst surgery; Scolicidal agent; Chlorhexidine gluconate; Hypertonic saline; Hydatid cyst recurrence. Intervention 1: Group 1: Hypertonic saline group Group 2: Chlorhexidine gluconate at a concentration of 0.04% as a scoliosis agent during liver hydatid cyst surgery; topical application within the surgical field and cystic cavity according to standard open surgical technique; once during surgery. Intervention 2: Intervention group: Hypertonic saline as a scolicidal agent during hepatic hydatid cyst surgery; topical application in the operative field and cyst cavity; single use during surgery. No - There is not a plan to make this available Justification or reason for not sharing IPD is Due to the single-center design, limited sample size, and to ensure confidentiality of patient information, there is no plan to share individual participant data outside the research team.