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IRCT201202281556N36 IRCT 2012-03-01 Tehran University of Medical Sciences Saffron versus fluoxetine for depression in post-PCI patients Saffron versus fluoxetine in the treatment of mild to moderate depression in post PCI patients: a double blind randomized clinical trial 2012-03-05 anticipated 50 Complete https://irct.ir/trial/886 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Major Depression. Intervention 1: Saffron Capsule maximum 30 mg/day for six weeks. Intervention 2: Fluoxetine Capsule maximum 40 mg/day for six weeks.
public Shahin Akhondzadeh
Roozbeh hospital
Tehran Iran (Islamic Republic of) +98 21 6641 8466 s.akhond@sina.tums.ac.ir Tehran University of Medical Sciences scientific Shahin Akhondzadeh
Roozbeh Hospital
Tehran Iran (Islamic Republic of) +98 21 6641 8466 s.akhond@sina.tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Inclusion: 1. Patients underwent angioplasty 2. Have depression based on DSM-IV-TR and score of 14-22 on Hamilton Depression Rating Scale 3. Informed consent Exclusion : 1.Psychosis 2. Current use of other psychotropic agents 3.Antidepressant in the last month 4.ECT in the previous two months 5- Thyroid problem 6.Lactation and pregnancy 7. Problems in other DSM axes 8.History of substance abuse or dependence during the last three months 9. High risk of suicide 10. Oral contraception use 11. Women of child-bearing if willing to be pregnant 12.Need for unusual psychiatric treatment 20 years 65 years Both F32 Treatment - Drugs Treatment - Drugs Saffron Capsule maximum 30 mg/day for six weeks Fluoxetine Capsule maximum 40 mg/day for six weeks Severity of Depressive symptoms. Timepoint: Weeks 0, 3 and 6. Method of measurement: Hamilton Depression Rating Scale-17 item. Side effects. Timepoint: Weeks 1, 3 and 6. Method of measurement: Side-effect Checklist. Tehran University of Medical Sciences Approved 2012-02-20 Tehran University of Medical Sciences Keshavarz Boulevard Tehran Iran (Islamic Republic of)