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IRCT20251231068515N1 IRCT 2026-05-13 Esfahan University of Medical Sciences Comparing the effect of 5% minoxidil and platelet-rich plasma combination with 5% minoxidil solution in androgenetic alopecia. Comparing the effect of 5% minoxidil and platelet-rich plasma combination with 5% minoxidil solution in androgenetic alopecia. 2026-06-20 anticipated 42 Pending https://irct.ir/trial/88993 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Eligible patients meeting the inclusion criteria will be randomly allocated into two intervention groups using a random number table before initiation of treatment: Group 1: Combined therapy with PRP + 5% minoxidil Group 2: Monotherapy with 5% minoxidil Participants will remain unaware of their group assignment until the start of the intervention, ensuring initial patient blinding until treatment commencement. Allocation will be performed at a 1:1 ratio without stratification, with each patient having an equal probability of assignment to either group. Note: Given the nature of the intervention (PRP injection), complete patient blinding throughout the study is not feasible. However, outcome assessment (trichoscopy and photography) will be performed by an evaluator blinded to group allocation to minimize bias. 3 androgenetic alopecia. Intervention 1: Intervention group: platelet rich plasma, administrated two times with 3 month interval via intradermal scalp injections by a dermatologist under sterile conditions AND topical minoxidil 5%, about 1ml administrated on scalp skin two times per day for 3 months. Intervention 2: Control group: topical minoxidil 5%, about 1ml administrated on scalp skin two times per day for 3 months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is there is no further information
public Fariba Iraji
Sofeh Blvd
Isfahan Iran (Islamic Republic of) 7573181746 +98 31 3822 0000 iraji@med.mui.ac.ir Esfahan University of Medical Sciences scientific Fariba Iraji
Sofeh Blvd
Isfahan Iran (Islamic Republic of) 7573181746 +98 31 3822 0000 iraji@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Patient consent Diagnosis confirmed by a specialist physician Age between 18 and 45 years No history of cardiovascular disease and no use of antihypertensive medications No other types of alopecia or any systemic dermatologic disease No pregnancy, breastfeeding, or menopause in female participants No pharmacological treatment for alopecia within the past 6 months 18 years 45 years Both Development of adverse reactions or hypersensitivity to the treatment Lack of participant compliance or withdrawal from the study for any reason L64 Androgenic alopecia Treatment - Drugs Treatment - Drugs Intervention group: platelet rich plasma, administrated two times with 3 month interval via intradermal scalp injections by a dermatologist under sterile conditions AND topical minoxidil 5%, about 1ml administrated on scalp skin two times per day for 3 months Control group: topical minoxidil 5%, about 1ml administrated on scalp skin two times per day for 3 months Hair density. Timepoint: before intervention, 6 month after intervention. Method of measurement: trichometer device. Hair thickness. Timepoint: before intervention, 6 month after intervention. Method of measurement: terichometer device. Patient satisfaction. Timepoint: 6 month after intervention. Method of measurement: Patient satisfaction score with treatment: (based on a 7-point scale). Esfahan University of Medical Sciences Approved 2025-12-29 Research Ethics Committees of School of Medicine - Isfahan University of Medical Sciences hezar jerib Ave isfahan Isfehan Iran (Islamic Republic of)