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IRCT20260414069075N1 IRCT 2026-05-05 Shiraz University of Medical Sciences The Effect of Aromatherapy with Orange and Peppermint Scents on Reducing Nausea, Vomiting, and Anxiety in Children Undergoing Chemotherapy Comparison of the Effect of Aromatherapy with Orange and Peppermint Essential Oils on Nausea, Vomiting, and Anxiety in Children with Cancer Undergoing Chemotherapy Referred to Hospitals and Clinics Affiliated with Shiraz University of Medical Sciences 2026-05-24 anticipated 120 Complete https://irct.ir/trial/89480 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: The randomization process will utilize permuted block randomization to assign the participants to the three study groups. A total of 120 participants will be allocated using 20 blocks of size six, Blinding description: The data analyst will be blinded to the allocation of groups to active intervention or placebo groups to prevent potential bias in interpretation the results. The allocation of groups will be disclosed to the analyst once the analysis is fully completed. N/A Condition 1: Nausea and Vomiting. Condition 2: Anxiety. Intervention 1: Intervention group: In the orange essential oil aromatherapy group, in addition to routine ward care, aromatherapy will be administered using two drops of orange essential oil placed on a 2x2 cm gauze pad. This pad will be attached to the child's collar with a pin, 20 cm from the child's nose. The child will be asked to breathe normally for twenty minutes. Intervention 2: Intervention group: In the peppermint essential oil aromatherapy group, in addition to routine ward care, aromatherapy will be administered using two drops of peppermint essential oil placed on a 2x2 cm gauze pad. This pad will be attached to the child's collar with a pin, 20 cm from the child's nose. The child will be asked to breathe normally for twenty minutes. Intervention 3: Control group: In the placebo group, in addition to routine ward care, aromatherapy will be simulated using two drops of liquid paraffin placed on a 2x2 cm gauze pad. This pad will be attached to the child's collar with a pin, 20 cm from the child's nose. The child will be asked to breathe normally for twenty minutes. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Its release schedule is not yet known
public Narges Rahimi
Nursing and midwifery school, Namazi square, Shiraz
Shiraz Iran (Islamic Republic of) 7193613119 +98 71 3647 4254 nargesrahimi.hr@gmail.com Shiraz University of Medical Sciences scientific Dr. Neda Jamali Moghadam
Nursing and Midwifery school, Namazi square, Shiraz
Shiraz Iran (Islamic Republic of) 7193613119 +98 71 3647 4254 nedajamali21@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Children aged 9–12 years of both genders Ability to understand and speak Persian No history of hypersensitivity, allergic rhinitis, and asthma or known respiratory problems Having a healthy sense of smell Receiving chemotherapy with drugs that have moderate to severe emetogenic potential Not having diseases that lead to vomiting The patient’s ability to determine the severity of nausea, vomiting, and anxiety according to the protocol No history of psychological problems or anxiety disorders according to self-report No use of sedative or anxiolytic drugs A history of receiving at least one session of chemotherapy, and reporting nausea and vomiting after that 9 years 12 years Both Lack of willingness of the child and parents to perform the intervention Sensitivity to herbal essential oils Use of other complementary medicine methods R11 F06.4 Nausea and vomiting Anxiety disorder due to known physiological condition Rehabilitation Rehabilitation Placebo Intervention group: In the orange essential oil aromatherapy group, in addition to routine ward care, aromatherapy will be administered using two drops of orange essential oil placed on a 2x2 cm gauze pad. This pad will be attached to the child's collar with a pin, 20 cm from the child's nose. The child will be asked to breathe normally for twenty minutes. Intervention group: In the peppermint essential oil aromatherapy group, in addition to routine ward care, aromatherapy will be administered using two drops of peppermint essential oil placed on a 2x2 cm gauze pad. This pad will be attached to the child's collar with a pin, 20 cm from the child's nose. The child will be asked to breathe normally for twenty minutes. Control group: In the placebo group, in addition to routine ward care, aromatherapy will be simulated using two drops of liquid paraffin placed on a 2x2 cm gauze pad. This pad will be attached to the child's collar with a pin, 20 cm from the child's nose. The child will be asked to breathe normally for twenty minutes. Nausea score on the Adapted Rhodes Index of Nausea and Vomiting for Pediatric. Timepoint: Before intervention, 12 and 24 hours after chemotherapy. Method of measurement: Adapted Rhodes Index of Nausea and Vomiting for Pediatric. Vomiting score on the Adapted Rhodes Index of Nausea and Vomiting for Pediatric. Timepoint: Before intervention, 12 and 24 hours after chemotherapy. Method of measurement: Adapted Rhodes Index of Nausea and Vomiting for Pediatric. Anxiety score on the Spielberger's State-Trait Anxiety Inventory for Children. Timepoint: Before intervention, 12 and 24 hours after chemotherapy. Method of measurement: Spielberger's State-Trait Anxiety Inventory for Children. Shiraz University of Medical Sciences Approved 2026-01-31 Ethics committee of Shiraz University of Medical Sciences Nursing and Midwifery school, Namazi square, Shiraz Shiraz Fars Iran (Islamic Republic of)