]>
IRCT20251231068511N1 IRCT 2026-07-21 Zahedan University of Medical Sciences Evaluation of The Effeect of Intravenous Hydrocortisone Administration on posst-Anesthesia General Sore Throat Evaluation of the Effect of Intravenous Hydrocortison Administration on post-Anesthesi General Sore Throat 2026-06-04 anticipated 56 Complete https://irct.ir/trial/89486 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Participants will be randomly assigned to the intervention or control group using simple randomization. Randomization will be performed using a random number table until the required sample size for each group is reached. Even numbers will be assigned to the hydrocortisone intervention group, and odd numbers will be assigned to the control group, Blinding description: The study will be conducted as a double-blind trial, where both the participants and the outcome assessor are blinded to the treatment allocation. Allocation concealment will be ensured using sequentially numbered, opaque, sealed envelopes (SNOSE). The randomization sequence will be generated first; then, the allocation will be written on a card and placed inside each envelope in the generated order. The envelopes will be numbered sequentially on the outside and placed in a box. Upon enrollment, each participant will receive the next available envelope in the sequence to determine their treatment assignment. 3 Evaluation of the Effect of Intravenous Hydrocortisone Administration on Postoperative Sore Throat Following General Anesthesia. Intervention 1: Intervantion group:Participants in this group will receive intravenous hydrocortisone at a dose of 1.5 mg/kg diluted in a 10-cc syringe administered as an intravenous infusion over 10 minutes before induction of general anesthesia. Intervention 2: Control group: Participants in this group will receive 10 cc of normal saline administered as an intravenous infusion over 10 minutes before induction of general anesthesia. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Sareh Raeisi
Persian Gulf Boulevard, Dr. Hesabi Square, University of Medical Sciences Campus,
Zahedan Iran (Islamic Republic of) 9914787697 +98 915 952 2512 sare4884@gmail.com Zahedan University of Medical Sciences scientific Sareh Raeisi
Second Floor,Central Headquarters Building,Univercity of Medical Sciences Campus,Dr.Hesabi Square,Zahedan
Zahedan Iran (Islamic Republic of) 9816743463 +98 54 3337 2113 sare4884@gmail.com Zahedan University of Medical Sciences Iran (Islamic Republic of) The patıent must be wıllıng to partıcıpate ın the study The patıent must be between 18 and 65 years old no underlyıng condıtıon The patient must be candidate for general anesthesia 18 years 65 years Both Drug allergy to Hydrocortıson Multıpple attempts at ıntubatıon Hıstory of chronıc sore throat Hıstory of recent Upper Respıratory Tract Infectıon Prevention Prevention Intervantion group:Participants in this group will receive intravenous hydrocortisone at a dose of 1.5 mg/kg diluted in a 10-cc syringe administered as an intravenous infusion over 10 minutes before induction of general anesthesia. Control group: Participants in this group will receive 10 cc of normal saline administered as an intravenous infusion over 10 minutes before induction of general anesthesia. Severıty score of postoperatıve sore throat followıng tracheal extubatıon after general anesthesıa. Timepoint: Assessment of postoperatıve sore throat severıty upon admıssıon to the recovery room ,and at 6 and 24 hours after tracheal extubation. Method of measurement: Based on the Visual Analugue Scale pain scale. Zahedan University of Medical Sciences Approved 2025-02-08 Ethics Committee of Zahedan University of Medical Sciences Persian Gulf Boulevard, Dr.Hesabi Square University of Medical Sciences Campus, Central Headquarters Building, Second Floor. Zahedan Sistan-va-Balouchestan Iran (Islamic Republic of)