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IRCT20090801002266N23 IRCT 2026-05-31 Esfahan University of Medical Sciences Evaluation of adding Cafein to SSRI in pationts with Obsessive-Compulsive Disorders Effectiveness of Caffeine Augmentation in Partial-Response Obsessive Compulsive disorder Patients Treated with Selective serotonin reuptake inhibitors (SSRIs) 2026-05-22 anticipated 130 Recruiting https://irct.ir/trial/90257 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization of patients between two groups is done with random assignment software. In this software, the total volume of the sample and the number of groups are entered into the software. The output of the software is a list that shows the total number of samples numerically and randomly distributed in two groups. Patients are distributed in two groups according to the time of visit and according to the mentioned list, so that the sample size reaches the required number, Blinding description: The study was double-blind, and the researcher and the patients were unaware of the type of drug received. Allocation of drug packages to patients will be done by the pharmacist using random coding. The researchers will only receive the random code and will not know the drug or placebo content until the end of the data analysis. 3 Obsessive Compolsive Disorder. Intervention 1: Intervention group: Received Cafeine 100 mg for one week, then 200 mg cafeine for tnd week and then 300 mg cafeine for third week. Intervention 2: Control group: Received plaseboo for three weeks same to intervention group. No - There is not a plan to make this available Justification or reason for not sharing IPD is The plan bellonging to goverment and we cant sharing it.
public Gholamreza Kheirabadi
Clinical psychology department, Noor & Ali Asghar hospital, Ostandari street, Isfahan, Iran
Isfahan Iran (Islamic Republic of) 8434193474 +98 31 3669 2174 kheirabadi@bsrc.mui.ac.ir Esfahan University of Medical Sciences scientific Gholamreza Kheirabadi
Department of clinical psychology, Noor & Ali Asghar hospital, Ostandari street, Isfahan, Iran
Isfahan Iran (Islamic Republic of) 8434193474 +98 31 3669 2174 kheirabadi@bsrc.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) CD diagnosis based on clinical interview based on DSM5 clinical criteria Outpatients with at least 12 weeks (3 months) of SSRI treatment and partial response. Ability to read and write Patient consent to participate in the study 18 years 55 years Both Pregnancy Drug abuse (based on patient report or file contents) Existence of suicidal thoughts (based on the report or content of the patient's file) The presence of psychotic symptoms based on the patient's report Diseases that can prevent the use of caffeine Taking other medications along with an SSRI, including antipsychotics, anticonvulsants, stimulants, or other augmenting medications, or taking more than one type of SSRI Excessive caffeine consumption F42.0 Obsessive-compulsive disorder Treatment - Drugs Treatment - Drugs Intervention group: Received Cafeine 100 mg for one week, then 200 mg cafeine for tnd week and then 300 mg cafeine for third week. Control group: Received plaseboo for three weeks same to intervention group. Obsessive Compulsive disorder scale. Timepoint: At statrt and end of intervention. Method of measurement: With Y-BOCS questionnaire. Esfahan University of Medical Sciences Approved 2026-02-20 Ethics committee of Isfahan University of Medical Sciences Research faculty, Isfahan University of Medical Sciences, Hezar Jerib street, Isfahan, Iran Isfahan Isfehan Iran (Islamic Republic of)