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IRCT20260519069451N1 IRCT 2026-07-22 Esfahan University of Medical Sciences Effect of Magnetic Brain Stimulation in Two Different Regions on OCD Symptoms DLPFC-SMA-OCD Comparative Study of the Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Two Anatomical Regions of the Right DLPFC and the SMA on the Symptoms of Patients With Obsessive-Compulsive Disorder 2026-06-22 anticipated 64 Complete https://irct.ir/trial/90274 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In the sampling method, 32 randomized blocks of two are used. In this way, every two individuals who enter the study according to the inclusion and exclusion criteria form a block of two. The participant with the lower national ID number is assigned the number 1, and the other participant is assigned the number 2. Then, we receive a random number from a calculator; if the number 0, 1, 2, 3, or 4 is received, participant number 1 will be assigned to the DLPFC group, and participant number 2 will be assigned to the SMA group. If the numbers 5, 6, 7, 8, or 9 are received, participant number 1 will be assigned to the SMA group, and participant number 2 will be assigned to the DLPFC group. N/A Obsessive-Compulsive Disorder (OCD) is a chronic psychiatric disorder characterized by the presence of obsessions (recurrent, intrusive, and unwanted thoughts, urges, or images) and/or compulsions (repetitive behaviors or mental acts performed to reduce anxiety or distress). OCD can significantly impair social, occupational, and academic functioning and reduce quality of life. Although pharmacotherapy and cognitive behavioral therapy are effective for many patients, a considerable proportion of individuals experience persistent symptoms, highlighting the need for alternative treatment approaches such as repetitive transcranial magnetic stimulation (rTMS).. Intervention 1: Intervention group: the right DLPFC group; individuals receiving rTMS on the right DLPFC area. The intervention will be delivered in 15-minute sessions, five times a week for 10 sessions. All patients will receive routine pharmacological treatment for obsessive-compulsive disorder. Intervention 2: Intervention group: the SMA group; individuals receiving rTMS on the SMA area. The intervention will be delivered in 15-minute sessions, five times a week for 10 sessions. All patients will receive routine pharmacological treatment for obsessive-compulsive disorder. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Individual participant data will not be shared due to privacy and confidentiality considerations and institutional restrictions regarding the dissemination of patient-level data.
public Faranak Zakizadeh
Isfahan Medical School, Isfahan University of Medical Sciences, Hezarjarib Ave., Isfahan
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3792 8134 faranak@med.mui.ac.ir Esfahan University of Medical Sciences scientific Faranak Zakizadeh
Isfahan Medical School, Isfahan University of Medical Sciences, Hezarjarib Ave., Isfahan
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3792 8134 faranak@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Adults aged between 18 and 65 years old Individuals with a confirmed diagnosis of OCD based on DSM-5 criteria Individuals who are capable of providing informed consent 18 years 65 years Both Participants who have a history of seizure or epilepsy Participants who have metal implants in or near the head Participants who have significant neurological or psychiatric disorders (e.g., schizophrenia, bipolar disorder) Participants who have a history of substance abuse within the past 6 months Participants who are currently pregnant or lactating F42 Obsessive-compulsive disorder Treatment - Other Treatment - Other Intervention group: the right DLPFC group; individuals receiving rTMS on the right DLPFC area. The intervention will be delivered in 15-minute sessions, five times a week for 10 sessions. All patients will receive routine pharmacological treatment for obsessive-compulsive disorder. Intervention group: the SMA group; individuals receiving rTMS on the SMA area. The intervention will be delivered in 15-minute sessions, five times a week for 10 sessions. All patients will receive routine pharmacological treatment for obsessive-compulsive disorder. Decreasing of obsessive compulsive symptoms. Timepoint: Before the intervention, immediately after the final session of the intervention, and 4 weeks after the final session. Method of measurement: Yale Brown obsessive compulsive scale. Esfahan University of Medical Sciences Approved 2025-11-22 Research Ethics Committees of School of Medicine - Isfahan University of Medical Sciences Isfahan Medical School, Isfahan University of Medical Sciences, Hezar Jerib Avenue, Isfahan, Isfahan, Iran Isfahan Isfehan Iran (Islamic Republic of)