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IRCT20260604069641N1 IRCT 2026-07-24 University of Science and Art, Yazd, Iran Comparison of psychological treatments for OCD comparative examination of mindfulness‑based compassion therapy and eye movement desensitization and reprocessing therapy with pharmacological control on emotion regulation, psychological adjustment, and anxiety in patients with obsessive–compulsive disorder 2026-06-26 anticipated 45 Complete https://irct.ir/trial/90631 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Participants will be assigned to one of three groups—Mindfulness-Based Compassion Therapy (MBCT), Eye Movement Desensitization and Reprocessing (EMDR), or the control group—using a simple randomization method, with individual participants serving as the unit of randomization. To generate the allocation sequence, a series of random numbers will be produced using the random number generator function in SPSS (version 26.0). Allocation will be based on the generated numbers: numbers assigned to the MBCT group will be designated as ‘1’, numbers for the EMDR group as ‘2’, and numbers for the control group as ‘3’. To ensure strict allocation concealment, this sequence will be managed by an independent researcher who will have no involvement in the recruitment, clinical assessment, or treatment delivery. Prior to the start of the study, the independent researcher will prepare sequentially numbered, opaque, and sealed envelopes, each containing the group assignment (1, 2, or 3) based on the pre-generated random sequence. Upon enrollment and after obtaining written informed consent, the researcher/assessor will open the next available envelope in the sequence and assign the participant to the corresponding group, Blinding description: This study is conducted in a single-blind manner. Questionnaires are recorded with anonymous codes and delivered to the outcome assessor and data analyst. N/A Obsessions and compulsions. Intervention 1: "Intervention group1:" The primary intervention is based on the Mindfulness-Based Compassion Training protocol, adapted from the model by Pirzad et al. (2024). This intervention will be conducted in eight weekly 90-minute sessions at the Armana Clinic in Yazd. Session 1: Introduction to Obsessive-Compulsive Disorder (OCD), mindfulness, and self-compassion, focusing on their role in reducing hopelessness. Exercises include breathing awareness and non-judgmental observation of obsessive thoughts. Session 2: Distinguishing between “thoughts,” “emotions,” and “obsessive behaviors,” emphasizing non-reactive observation. Practice of body scan with a compassionate approach toward unpleasant experiences. Session 3: Identifying difficult emotions associated with OCD (anxiety, shame, hopelessness) and fostering acceptance. Exercises focus on compassion-focused breathing and cultivating a sense of safety when facing threatening emotions. Session 4: Examining the role of self-blame and self-criticism in the maintenance of OCD. Practice of compassionate self-talk in response to obsessive thoughts and perceived mistakes. Session 5: Training in compassionate responses to obsessive thoughts as an alternative to avoidance or struggle. Exercises in experiencing acceptance with kindness, without the urge for immediate control. Session 6: Training in emotion regulation strategies based on the mindfulness and self-compassion model. Session 7: Practicing the “Mindful Pause” in OCD-triggering situations. Application of mindfulness and compassion to daily life challenges and OCD symptoms. Session 8: Mindful exposure to obsessive thoughts while maintaining a compassionate attitude. Review of acquired skills and the role of self-compassion in reducing hopelessness and enhancing psychological adjustment. Development of a personalized self-care and mindfulness plan for relapse prevention and sustained improvement.The therapeutic process is structured across eight distinct sessions, each carefully sequenced to build upon the foundational knowledge and skills established in preceding sessions. This hierarchical progression ensures that clients are adequately prepared and resourced at each stage, facilitating a systematic and cumulative approach to achieving therapeutic objectives. Intervention 2: "Intervention group 2:" The second intervention is based on the Eye Movement Desensitization and Reprocessing (EMDR) protocol, adapted from the model by Dreessen et al. (2024). This intervention will be implemented weekly in eight 45-minute sessions at the Armana Clinic in Yazd. Phase 1 (History Taking and Treatment Planning): Gathering baseline information, including family history, clinical background, current symptomatology, and the client’s existing social support system. Phase 2 (Preparation): Educating and preparing the client for processing traumatic memories. This phase involves teaching coping skills, pain management techniques, and relaxation exercises to be practiced between sessions. Phase 3 (Assessment): Identifying the target memory, selecting a negative cognition (NC), and establishing a positive cognition (PC). The client’s Subjective Units of Disturbance (SUD) scale and Validity of Cognition (VoC) scale are assessed and recorded. Phase 4 (Desensitization): The client focuses on the distressing image, negative beliefs, and associated physical sensations while receiving bilateral stimulation (BLS) through eye movements. This process continues until the intensity of the distress is reduced to a manageable level. Phase 5 (Installation): The goal is to strengthen the positive cognition and replace the negative belief associated with the traumatic memory with a more adaptive, positive one. Phase 6 (Body Scan): The client performs a head-to-toe body scan to identify any remaining physical tension. Bilateral stimulation is utilized to process and release these somatic sensations, fostering a sense of relief and well-being. Phase 7 (Closure): The client reflects on their current emotional and cognitive state. The therapist ensures the client ends the session in a stable and balanced state. Phase 8 (Re-evaluation): Reviewing treatment goals, conducting a follow-up assessment of the client’s progress, and concluding the therapy process.The therapeutic process is structured across eight distinct sessions, each carefully sequenced to build upon the foundational knowledge and skills established in preceding sessions. This hierarchical progression ensures that clients are adequately prepared and resourced at each stage, facilitating a systematic and cumulative approach to achieving therapeutic objectives. Intervention 3: Control group: will receive no therapeutic intervention during the study period, serving as a baseline for comparison with the experimental group. No - There is not a plan to make this available Justification or reason for not sharing IPD is To protect the privacy and confidentiality of the participants, raw individual-level data (IPD) will not be shared publicly. The study adheres to strict ethical guidelines regarding data protection to ensure that no participant can be identified from the shared information.
public Sepideh Semsar Yazdi
No.6, Alley 8, Amir Kabir Blvd, University Town,Yazd,Iran
Yazd Iran (Islamic Republic of) 8916147164 +98 35 3821 2747 sepidehsemsaryazdi@gmail.com University of Science and Art, Yazd, Iran scientific Dr.Mohsen Saeidmanesh
Armana Psychology Clinic, Hazrat Abbas St., Jomhouri Eslami Blvd., Yazd, Iran.
Yazd Iran (Islamic Republic of) 8917945730 +98 35 3530 4351 m.saeidmanesh@yahoo.com University of Science and Art, Yazd, Iran Iran (Islamic Republic of) Suffering from obsessive-compulsive disorder (OCD) OCD of the type of contamination, washing and checking Treatment started less than six months ago in the sample Having minimum reading and writing skills to answer questionnaire questions Receive fixed drug treatment (Asentra 100 mg) Availability to fully attend therapy sessions 25 years 45 years Both History of psychotic or bipolar disorders History of suicide attempt in the last 6 months Receiving other structured psychotherapy at the same time Starting, stopping, or changing the dose of psychiatric medication within 8 weeks prior to study entry Presence of severe learning disabilities or neurological disorders Drug use or alcohol dependence in the last 6 months F42 Obsessive-compulsive disorder Treatment - Other Treatment - Other N/A "Intervention group1:" The primary intervention is based on the Mindfulness-Based Compassion Training protocol, adapted from the model by Pirzad et al. (2024). This intervention will be conducted in eight weekly 90-minute sessions at the Armana Clinic in Yazd. Session 1: Introduction to Obsessive-Compulsive Disorder (OCD), mindfulness, and self-compassion, focusing on their role in reducing hopelessness. Exercises include breathing awareness and non-judgmental observation of obsessive thoughts. Session 2: Distinguishing between “thoughts,” “emotions,” and “obsessive behaviors,” emphasizing non-reactive observation. Practice of body scan with a compassionate approach toward unpleasant experiences. Session 3: Identifying difficult emotions associated with OCD (anxiety, shame, hopelessness) and fostering acceptance. Exercises focus on compassion-focused breathing and cultivating a sense of safety when facing threatening emotions. Session 4: Examining the role of self-blame and self-criticism in the maintenance of OCD. Practice of compassionate self-talk in response to obsessive thoughts and perceived mistakes. Session 5: Training in compassionate responses to obsessive thoughts as an alternative to avoidance or struggle. Exercises in experiencing acceptance with kindness, without the urge for immediate control. Session 6: Training in emotion regulation strategies based on the mindfulness and self-compassion model. Session 7: Practicing the “Mindful Pause” in OCD-triggering situations. Application of mindfulness and compassion to daily life challenges and OCD symptoms. Session 8: Mindful exposure to obsessive thoughts while maintaining a compassionate attitude. Review of acquired skills and the role of self-compassion in reducing hopelessness and enhancing psychological adjustment. Development of a personalized self-care and mindfulness plan for relapse prevention and sustained improvement.The therapeutic process is structured across eight distinct sessions, each carefully sequenced to build upon the foundational knowledge and skills established in preceding sessions. This hierarchical progression ensures that clients are adequately prepared and resourced at each stage, facilitating a systematic and cumulative approach to achieving therapeutic objectives. "Intervention group 2:" The second intervention is based on the Eye Movement Desensitization and Reprocessing (EMDR) protocol, adapted from the model by Dreessen et al. (2024). This intervention will be implemented weekly in eight 45-minute sessions at the Armana Clinic in Yazd. Phase 1 (History Taking and Treatment Planning): Gathering baseline information, including family history, clinical background, current symptomatology, and the client’s existing social support system. Phase 2 (Preparation): Educating and preparing the client for processing traumatic memories. This phase involves teaching coping skills, pain management techniques, and relaxation exercises to be practiced between sessions. Phase 3 (Assessment): Identifying the target memory, selecting a negative cognition (NC), and establishing a positive cognition (PC). The client’s Subjective Units of Disturbance (SUD) scale and Validity of Cognition (VoC) scale are assessed and recorded. Phase 4 (Desensitization): The client focuses on the distressing image, negative beliefs, and associated physical sensations while receiving bilateral stimulation (BLS) through eye movements. This process continues until the intensity of the distress is reduced to a manageable level. Phase 5 (Installation): The goal is to strengthen the positive cognition and replace the negative belief associated with the traumatic memory with a more adaptive, positive one. Phase 6 (Body Scan): The client performs a head-to-toe body scan to identify any remaining physical tension. Bilateral stimulation is utilized to process and release these somatic sensations, fostering a sense of relief and well-being. Phase 7 (Closure): The client reflects on their current emotional and cognitive state. The therapist ensures the client ends the session in a stable and balanced state. Phase 8 (Re-evaluation): Reviewing treatment goals, conducting a follow-up assessment of the client’s progress, and concluding the therapy process.The therapeutic process is structured across eight distinct sessions, each carefully sequenced to build upon the foundational knowledge and skills established in preceding sessions. This hierarchical progression ensures that clients are adequately prepared and resourced at each stage, facilitating a systematic and cumulative approach to achieving therapeutic objectives. Control group: will receive no therapeutic intervention during the study period, serving as a baseline for comparison with the experimental group Severity of obsessive-compulsive symptoms (OCD). Timepoint: Pre-intervention, immediately post-intervention, and 4 weeks post-intervention. Method of measurement: Clinical Assessment. Anxiety. Timepoint: Pre-intervention, immediately post-intervention, and 4 weeks post-intervention. Method of measurement: Beck Anxiety Inventory(Beck et al.,1990). Psychological adjustment. Timepoint: Pre-intervention, immediately post-intervention, and 4 weeks post-intervention. Method of measurement: Bell Adjustment Inventory(1961). Emotion regulation. Timepoint: Pre-intervention, immediately post-intervention, and 4 weeks post-intervention. Method of measurement: Emotion Regulation Questionnaire(Gross & John,2003). University of Science and Art, Yazd, Iran Approved 2026-05-09 Ethics committee of University of Science and Culture, Jihad Daneshgahi Bahar Ave., Shahid Ghamoshi., Ashrafi Esfahani Blvd Tehran Tehran Iran (Islamic Republic of)