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IRCT20260607069676N1 IRCT 2026-06-20 Hakim Sabzevari University The effect combined training and NBS Supplementation on Type 2 Diabetes The effect of combined training and Nutrition Bio-shield Superfood (NBS) Supplementation on some factors affecting Epigenetic Changes in Obese Men with Type 2 Diabetes 2026-06-22 anticipated 48 Complete https://irct.ir/trial/90644 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Other, Purpose: Treatment, Randomization description: In this study, after selecting the subjects, the subjects will be randomly divided into four groups. Simple Random Assignment is the method used for this purpose. In this method, each subject is assigned independently of the others and with equal probability (25%) to one of the four groups (combined exercise and supplementation, combined exercise and placebo, supplementation, placebo). Random assignment will be done using valid statistical software (such as SPSS, R or Excel) and using a random number generator, Blinding description: In this study, single-blinding will be used to control for potential bias and increase the validity of the findings. This means that subjects will be unaware of the type of intervention they are receiving (supplement or placebo) throughout the study. To implement this method, the supplement and placebo will be completely similar and indistinguishable in appearance, color, odor, taste, packaging, and method of administration. The products will be distributed by a third party (research collaborator) or using confidential codes so that subjects cannot identify whether they are in the intervention or control group. 2-3 Type 2 diabetes. Intervention 1: Intervention group 1: Combined exercise and NBS supplementation. Perform three sessions of resistance and aerobic exercise and take 10 drops of the supplement daily, equivalent to half a gram. Intervention 2: Intervention group 2: Combined exercise and placebo. Intervention 3: Intervention group3: NBS supplement. Dosage is the same as in the first group. Intervention 4: Control group: placebo. Yes - There is a plan to make this available What will be shared: Some information such as age, gender, weight, medical condition, medications taken When: 12 months after results are published To whom: University professors and students Conditions: Use for scientific activities Where to obtain: Send email to: Mohammadkgb79@yahoo.com How to obtain: Maximum one month Comments:
public Mohammad Khosravi Bakhtiari
Khaje rabie, 22 bahman Blvd, 22 bahman4/23, number 4
Mashhad Iran (Islamic Republic of) 9199786766 +98 51 3751 1058 mohammadkgb79@yahoo.com Hakim Sabzevari University scientific Mohammad Khosravi Bakhtiari
Khaje rabie, 22 bahman Blvd, 22 bahman4/23, number 4
Mashhad Iran (Islamic Republic of) 9199786766 +98 51 3751 1058 mohammadkgb79@yahoo.com دانشگاه حکیم سبزواری Iran (Islamic Republic of) No specific disease such as acute psychiatric disorders, cardiovascular, respiratory diseases, heart surgery, autoimmune diseases and arthritis. No limiting orthopedic conditions. Walk independently and be able to perform daily tasks. The dose of the medication has not changed in the past month. No history of regular exercise in the past three months No smoking Have a medical certificate from a specialist to confirm the ability to perform physical activity Uncontrolled arrhythmia Severe hearing impairment No insulin injection 45 years 55 years Male Failure to attend the training program for three consecutive sessions Personal problems Unwillingness to continue the research Injury Engaging in side activities Use of herbal supplements other than those used in the plan or chemical supplements E08 Diabetes mellitus due to underlying condition Treatment - Drugs Treatment - Devices Treatment - Drugs Placebo Intervention group 1: Combined exercise and NBS supplementation. Perform three sessions of resistance and aerobic exercise and take 10 drops of the supplement daily, equivalent to half a gram. Intervention group 2: Combined exercise and placebo Intervention group3: NBS supplement. Dosage is the same as in the first group. Control group: placebo Cd36. Timepoint: Before the intervention and 72 hours after the last intervention session. Method of measurement: ELISA laboratory kit. Betaine. Timepoint: Before the intervention and 72 hours after the last intervention session. Method of measurement: ELISA laboratory kit. DNMT3a. Timepoint: Before the intervention and 72 hours after the last intervention session. Method of measurement: ELISA laboratory kit. Hakim Sabzevari University Approved 2026-06-07 Ethics Committee of Hakim Sabzevari University Sabzevar, Tohidshahr, Pardis University sabzevar Razavi Khorasan Iran (Islamic Republic of)