IRCT20260611069751N1 IRCT 2026-06-23 Lady Reading Hospital Medical Teaching Institution (LRH-MTI) Effect of Ketamine gargles on sore throat after surgery KGPOST Comparison of frequency of post operative sore throat in patients undergoing oral endotracheal intubation with ketamine gargles and normal saline 2025-10-18 anticipated 156 Complete https://irct.ir/trial/90916 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Other design features: Single-blind, parallel-group interventional study. Participants were blinded to treatment allocation. Patients received either ketamine gargles or normal saline gargles on alternate study days. Investigators and care providers were aware of group allocation. Postoperative sore throat was assessed after oral endotracheal intubation, Blinding description: Participants were blinded to the allocated intervention. Patients were not informed whether they received ketamine gargles or normal saline gargles. The investigators and care providers were aware of the allocated intervention. Therefore, the study was conducted as a single-blind trial with participant blinding only. N/A Postoperative sore throat following oral endotracheal intubation. Intervention 1: Intervention group: Participants received ketamine gargles containing 50mg ketamine diluted in 29ml water and gargled for 40 seconds before induction of general anesthesia. Intervention 2: Control group: Participants received normal saline gargles of equal volume and gargled for 40 seconds before induction of general anesthesia. No - There is not a plan to make this available Justification or reason for not sharing IPD is Individual participant data will not be shared publicly to protect participant confidentiality and privacy .the study was conducted for academic purposes and no plan exists for public release of deidentified dataset.