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IRCT20260615069816N1 IRCT 2026-06-27 Islamic Azad University Comparison and effect of activation irrigation solution on postoperative endodontic pain Comparison and effect of activation irrigation with Ultra X device , Wave Q device and conventional irrigation of root canal with endodontic needle on postoperative endodontic pain 2025-09-25 anticipated 39 Complete https://irct.ir/trial/90948 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Diagnostic, Randomization description: The methodology section has been revised to provide detailed clarification regarding participant allocation. Randomization was performed using a simple lottery-based allocation method with opaque folded papers corresponding to each intervention group. Allocation was conducted prior to the irrigation procedure to minimize selection bias, Blinding description: This study was designed as a single-blind randomized clinical trial in which the patients were unaware of the irrigation activation method used during treatment. Due to the nature of the intervention, operator blinding was not feasible. 3 Post operative pain. Intervention group: type of activation irrigation solution. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is no more infotmation
public maryam zare jahromi
Daneshgah Blvd , Arghavanie , east Jey street , Isfahan
isfahan Iran (Islamic Republic of) 8155139998 +98 21 7731 9048 hiva1378maryam@gmail.com Islamic Azad University scientific zahra mohammadi
No 6, Yas avenue , Pormokhtar avenue , Bahar Blvd , Hakimiye , Tehran
tehran Iran (Islamic Republic of) 1695945866 +98 21 7731 9048 zmhmmdi1997@gmail.com Islamic Azad University Iran (Islamic Republic of) 1. Patients with good systemic health and no significant medical conditions (ASA I or II).2. Patients diagnosed with irreversible pulpitis with spontaneous pain and symptomatic apical periodontitis in single-rooted, single-canal premolar teeth.3. Patients capable of understanding the Visual Analog Scale (VAS) for pain assessment.4. Patients aged between 18 and 55 years.5. Patients who are willing to participate in the study and are able to provide written informed consent.6. Patients who are candidates for single-visit endodontic treatment 18 years 55 years Both 1. Patients with systemic diseases.2. Pregnant women and breastfeeding mothers.3. Patients requiring antibiotic prophylaxis.4. Patients with psychiatric disorders.5. Patients with a history of allergy to the medications or materials used in the study.6. Patients who had taken antibiotics or analgesics within 12 hours prior to treatment.7. Patients with a current or previous history of abscess formation or swelling in the periapical region.8. Teeth presenting any of the following conditions were excluded from the study: - Open apex or a wide apical foramen. - Necrotic teeth. - Presence of a fistula or sinus tract. - Acute or chronic periapical abscess. - Teeth with Grade II or III mobility. - Non-restorable or hopeless teeth. - Abnormal root canal anatomy or calcified canals.9. Teeth in which procedural errors occurred during root canal treatment.10. Teeth in which apical patency could not be established.11. Patients who developed a flare-up following treatment.12. Patients with stress, as determined by the stress assessment test N/A Intervention group: type of activation irrigation solution Post operative pain. Timepoint: 6, 12, 24, 48 , 72 hour and 1 week after treatment. Method of measurement: VAS pain score. Islamic Azad University Approved 2025-06-21 Ethics committee of Azad Islamic University Khorasgan branch Daneshgah Blvd , Arghavanie , east jey avenue , Isfahan Isfahan Isfehan Iran (Islamic Republic of)