IRCT201201098635N2 IRCT 2012-05-09 Research Deputy of Tehran University of Medical Sciences Evaluation of EUS-guided alcohol ablation effectiveness in treatment of insolinoma Evaluation of EUS-guided alcohol ablation effectiveness in treatment of insolinoma 2012-05-21 anticipated 10 Complete https://irct.ir/trial/9128 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 1 insulinoma. Intervention 1: After localizing the site of the tumor by EUS, fine needle aspiration of the tumor will be performed for cytological evaluation. At least three passes of FNA with a 22-guage needle (COOK) will be taken. The samples will be placed into 70% ethanol and sent for cell block preparation and cytological evaluation. Then, a total of 6 ml of 95% ethanol will be injected during the same session using linear array echo-endoscope guidance. The patients will be hospitalized for 48 hours. The patients will be received dextrose 10% (1000 ml every 8 hours) during the first 24 hours after alcohol injection. Periodic visits of the patient will be performed during the hospitalization. The patients will be monitored for any symptoms (e.g. abdominal pain, nausea, vomiting, etc.). Serum levels of amylase and lipase will be checked at hour 12, hour 24 and hour 48 post-procedure. Outcome measures: •Fasting plasma glucose level at day 0 (before the procedure), day 1, month 1, month 3, month 6, month 12 post-procedure •EUS of the pancreas to evaluate tumor remission at month 3, and month 12 post-procedure. Intervention 2: Control group: the patients with insulinoma treating by surgery.