]>
IRCT20260707070092N1 IRCT 2026-07-20 Esfahan University of Medical Sciences Comparison of the effects of Mesotherapy and Dry Needling on pain reduction and functional improvement in patients with Tennis Elbow MEDTEN Trial Comparison of the efficacy of Mesotherapy and Dry Needling in pain reduction and functional improvement in patients with Lateral Epicondylitis (Tennis Elbow): A Randomized clinical trial conducted at the physical medicine and rehabilitation clinics of Isfahan university of medical sciences. 2026-07-22 anticipated 58 Recruiting https://irct.ir/trial/91525 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be assigned to treatment groups using a fixed-block randomization method. Each block will consist of four patients, with assignment to the two treatment groups occurring at a 1:1 ratio. The randomization sequence will be generated using the Clinical Trial Randomization Tool provided by the National Cancer Institute (NCI). The randomization list will be kept confidential, and treatment group assignments will be made based on the order of patient enrollment in the study. 3 Lateral epicondylitis(Tennis elbow). Intervention 1: The study involves 58 patients randomly assigned to either the mesotherapy group or the dry needling group. In the mesotherapy intervention group, 1 cc of Piroxicam (20 mg/1 ml; Caspian Tamin Pharmaceutical Company) is administered subcutaneously using a 27-gauge needle at a 45-degree angle; a volume of 0.5 cc is injected into each of two tender points—to reduce inflammation and alleviate pain—twice weekly for a period of three weeks. Intervention 2: Second Intervention Group (Dry Needling Group): Patients in this group receive dry needling twice weekly combined with exercise therapy. The dry needling procedure involves using a 0.25 × 0.25 mm needle at the point of maximal tenderness over the lateral epicondyle; the "Hong fast-in-fast-out" technique is applied, consisting of 20 rapid insertions and withdrawals at the designated site over a 20-second period. Additionally, the Chou technique—involving simultaneous rotation during needle insertion and withdrawal—is employed to facilitate needle movement. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Due to the need to address ethical considerations and maintain the confidentiality of participants' data, the final decision regarding the release of the data file will be made upon completion of the study.
public Fatemeh Abasirad
No. 305, Kasra Building No. 7, C2 Neighborhood, Motahari Blvd, Fooladshahr, Isfahan
Esfahan Iran (Islamic Republic of) 8491421142 N/A fe.abasirad7374@gmail.com Esfahan University of Medical Sciences scientific Razieh Maghroori
Department of Physical Medicine and Rehabilitation, Al-Zahra Hospital, Isfahan University of Medical Sciences, Sofeh Blvd., Isfahan , Iran
Esfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 Ramaghroori@yahoo.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Age 18–70 years pain at the lateral epicondyle for at least one month Pain during at least one of the following tests: Maudsley’s test, Cozen ’s test (resisted extension of the middle finger), or Mill’s test. 18 years 70 years Both Cervical radiculopathy Neuropathy Arthritis or a history of arthritis in the upper extremity Pregnancy History of forearm or elbow surgery Acute elbow trauma Autoimmune disease Local or systemic upper-extremity infection Fibromyalgia syndrome Cubital tunnel syndrome Carpal tunnel syndrome Ipsilateral medial epicondylitis Old fracture in the affected arm Elbow deformity Presence of coagulation disorders General contraindications for mesotherapy (exclusion criteria to be considered for patients undergoing the procedure): bleeding disorders; active infections in the treatment area (such as open wounds, skin infections, or severe acne); autoimmune diseases (e.g., lupus or rheumatoid arthritis); use of blood-thinning medications; and chronic skin conditions (such as psoriasis, eczema, or rosacea). M77.1 Lateral epicondylitis Treatment - Drugs Treatment - Drugs The study involves 58 patients randomly assigned to either the mesotherapy group or the dry needling group. In the mesotherapy intervention group, 1 cc of Piroxicam (20 mg/1 ml; Caspian Tamin Pharmaceutical Company) is administered subcutaneously using a 27-gauge needle at a 45-degree angle; a volume of 0.5 cc is injected into each of two tender points—to reduce inflammation and alleviate pain—twice weekly for a period of three weeks. Second Intervention Group (Dry Needling Group): Patients in this group receive dry needling twice weekly combined with exercise therapy. The dry needling procedure involves using a 0.25 × 0.25 mm needle at the point of maximal tenderness over the lateral epicondyle; the "Hong fast-in-fast-out" technique is applied, consisting of 20 rapid insertions and withdrawals at the designated site over a 20-second period. Additionally, the Chou technique—involving simultaneous rotation during needle insertion and withdrawal—is employed to facilitate needle movement. Severity of pain associated with lateral epicondylitis (tennis elbow) in the study participants. Timepoint: Before the start of the study, Immediately after completion of the study,8 weeks after completion of the study. Method of measurement: Pain severity will be assessed using the Visual Analog Scale (VAS). Functional status and limitations in performing activities related to the upper extremity in patients with lateral epicondylitis(tennis elbow). Timepoint: Before the start of the study, Immediately after completion of the study,8 weeks after completion of the study. Method of measurement: Patient-Rated Tennis Elbow Evaluation (PRTEE). Esfahan University of Medical Sciences Approved 2026-06-20 Ethics Committee of Isfahan University of Medical Sciences. No.305,Kasra Building 7, C2 Neighborhood, Motahari Bolevard, Fooladshahr, Isfahan Fooladshahr Isfehan Iran (Islamic Republic of)