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IRCT201212178698N5 IRCT 2013-01-10 Tehran University of Medical Sciences Impact of l-carnitine on contrast induced nephropathy Impact of L-carnitine on contrast induced nephropathy in patients undergoing elective Percutaneous Coronary Intervention(PCI) 2012-12-30 anticipated 320 Complete https://irct.ir/trial/9182 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A ischemic heart disease. Intervention 1: 3 gram L - carnitine is administrated to intervention patients one day before catheterization (1 g every 8 hours) and lasts for up to 48 hour after it (for three days). Patients urine sample is collected at baseline and 12 hour after catheterization for determination of NGAL. Also serum creatinine and glumerular filtration is determined at baseline and 48 hour after catheterization. Intervention 2: Medication will not be given to patients in the control group.Patients urine sample is collected at baseline and 12 hour after catheterization for determination of NGAL. Also serum creatinine and glumerular filtration is determined at baseline and 48 hour after catheterization.
public Azita Hajhossein Talasaz
16 Azar St., School of Pharmacy, Tehran University of Medical Sciences
Tehran Iran (Islamic Republic of) +98 21 6695 4709 atalasaz@razi.tums.ac.ir Tehran University of Medical Sciences scientific Azita Hajhossein Talasaz, Kheirollah Gholami
16 Azar St., School of Pharmacy, Tehran University of Medical Sciences
Tehran Iran (Islamic Republic of) +98 21 6695 4709 atalasaz@razi.tums.ac.ir-kheirollah_gholami_2000@yahoo.com Tehran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria:Patients with ischemic heart disease that have more than 50 percent occlusion in angiography findings and candidates for elective Pecrcutaneous Coronary Intevention.Exclusion criteria: cardiogenic shock;ST Elevation Myocardial Infarction;pregnant and lactating womens;patients under 18 years;immunologic or hematologic disorders;current infection;chronic kidney disease;serum creatinine above 2.5 mg/dl;hypothyroidism;epilepsy or convulsion;chronic liver disease;cancer 18 years 90 years Male I20-I25 Myocardial ischemia followed by decreased oxygen to the myocardium Treatment - Drugs Other 3 gram L - carnitine is administrated to intervention patients one day before catheterization (1 g every 8 hours) and lasts for up to 48 hour after it (for three days). Patients urine sample is collected at baseline and 12 hour after catheterization for determination of NGAL. Also serum creatinine and glumerular filtration is determined at baseline and 48 hour after catheterization. Medication will not be given to patients in the control group.Patients urine sample is collected at baseline and 12 hour after catheterization for determination of NGAL. Also serum creatinine and glumerular filtration is determined at baseline and 48 hour after catheterization. (Neutrophil gelatinase-associated lipocalin (NGAL. Timepoint: baseline and 12 hour after. Method of measurement: Elisa kit. (Glomerular Filtration Rate (GFR. Timepoint: baseline and 48 hour after. Method of measurement: determination of serum creatinine by chromatography. Renal function. Timepoint: 1 month later. Method of measurement: evaluation of patient condition such as death and renal function. Tehran University of Medical Sciences Approved 2012-11-07 Tehran University of Medical Sciences 16 Azar St., Qhods St., Tehran University of Medical Sciences Tehran Iran (Islamic Republic of)