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IRCT20230714058773N5 IRCT 2026-07-30 Department of Oral and Maxillofacial Surgery, Islam Dental College, Sialkot Comparative Efficacy of Dexamethasone Versus Prednisone in the Prevention of Post-Operative Edema, Pain, and Trismus Following Mandibular Third Molar Surgery Comparative Efficacy of Dexamethasone Versus Prednisone in the Prevention of Post-Operative Edema, Pain, and Trismus Following Mandibular Third Molar Surgery 2026-01-02 anticipated 80 Complete https://irct.ir/trial/92003 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Supportive, Randomization description: Eligible participants were randomized in a 1:1 ratio using a computer-generated random number sequence (www.randomizer.org), with allocation concealment maintained through sequentially numbered, opaque, sealed envelopes prepared by an independent statistician not involved in patient care or outcome assessment, Blinding description: Eligible participants were randomized in a 1:1 ratio using a computer-generated random number sequence (www.randomizer.org), with allocation concealment maintained through sequentially numbered, opaque, sealed envelopes prepared by an independent statistician not involved in patient care or outcome assessment. N/A Impacted mandibular third molar. Intervention 1: Intervention group: Patients received dexamethasone 8 mg administered locally into pterygomandibular 20 minutes prior to the commencement of surgical extraction, plus an oral placebo capsule identical in appearance to the prednisone capsule. Intervention 2: Intervention group: Group B (Prednisone): 40 mg oral, 60 minutes pre-op, plus an intramasseteric normal saline injection. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Dr Tehmina Maryam
Islam Medical And Dental College, Pasrur road, sialkot, Pakistan
Sialkot Pakistan 51310 +98 33 3957 6737 tehminamaryam27@gmail.com Department of Oral and Maxillofacial Surgery, Islam Dental College, Sialkot scientific Noman
Islam Medical And Dental College, Pasrur road, sialkot, Pakistan
Sialkot Pakistan 51310 +98 33 3957 6737 tehminamaryam27@gmail.com Department of Oral and Maxillofacial Surgery, Islam Dental College, Sialkot Pakistan Patients were eligible for inclusion if they were aged 18–40 years, had a unilateral impacted mandibular third molar requiring surgical extraction under local anaesthesia, and were classified as American Society of Anesthesiologists (ASA) Physical Status Class I or II. The molar had to be classified as Class II Position B impaction on panoramic radiography (Pell and Gregory classification). 18 years 40 years Both Exclusion criteria encompassed active systemic illness (diabetes mellitus, hypertension, renal or hepatic disease), known hypersensitivity or contraindication to corticosteroids, current use of systemic corticosteroids or non-steroidal anti-inflammatory drugs, pregnant or lactating women, active pericoronitis or acute pericoronal infection at the surgical site, active peptic ulcer disease, immunocompromised status, and tobacco or alcohol use disorder. Patients who required general anaesthesia or sedation were also excluded K08.3 Retained dental root Other Other Intervention group: Patients received dexamethasone 8 mg administered locally into pterygomandibular 20 minutes prior to the commencement of surgical extraction, plus an oral placebo capsule identical in appearance to the prednisone capsule Intervention group: Group B (Prednisone): 40 mg oral, 60 minutes pre-op, plus an intramasseteric normal saline injection Facial edema. Timepoint: at day 2, day 5, day 7. Method of measurement: sum of 3 linear measurements. Primary: facial edema at baseline,. Timepoint: Day 2, Day 5, Day 7. Method of measurement: sum of 3 linear measurements. Secondary: VAS pain score (0–10), trismus , and adverse events (nausea/vomiting, hyperglycemia, insomnia, dry socket). Timepoint: immediately after, at day 2 and day 5 and 7. Method of measurement: visual analog scale, reduction in maximum interincisal distance from baseline. Department of Oral and Maxillofacial Surgery, Islam Dental College, Sialkot Approved 2026-02-02 Department of Oral and Maxillofacial Surgery, Islam Dental College, Sialkot, Pakistan Islam Medical And Dental College, Pasrur road, sialkot, Pakistan Sialkot punjab Pakistan