]>
IRCT20130812014333N282 IRCT 2026-07-31 Islamic Azad University, Khorasgan branch Comparison of corticosteroid mouthwashes, Betamethasone and Dexamethasone, in the treatment of patients with aphthous stomatitis and lichen planus Comparison of two types of corticosteroid mouthwashes, Betamethasone and Dexamethasone, in the treatment of patients with aphthous stomatitis and lichen planus 2026-08-16 anticipated 56 Complete https://irct.ir/trial/92041 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization using the blocking method with blocks in sizes 6 and 9. For randomization, the site https://www.sealedenvelope.com is used. All codes are recorded on paper and stored in specific envelopes. Each of the generated codes is kept separately inside the envelope and the secretary gives one of these envelopes to the patient before the patient enters the doctor's room. Accordingly, the next patient code is not predictable. The doctor determines which treatments to perform based on the patient's code. Only the physician performing the intervention will be aware of the code assigned to the patient. After evaluating the outcome, based on the patient's name, the collected information will be linked to the assigned code, Blinding description: In this double-blind study, patients are informed about their participation in the study. Both the researchers and participants were kept blinded to group allocation. To achieve this, identical unlabeled bottles were prepared and given to the patients using confidential coding. N/A Condition 1: oral aphthae. Condition 2: Lichen planus. Intervention 1: In the first intervention group, a combination of 6 vials of betamethasone ampoules, nystatin drops (100,000 units), aluminum hydroxide syrup (40 mg), and diphenhydramine syrup (160 mg) was prepared. Patients then used the betamethasone mouthwash three times a day for 2 minutes each time, over a period of 14 days. Intervention 2: In the second intervention group, a combination of 6 vials of dexamethasone ampoules, nystatin drops (100,000 units), aluminum hydroxide syrup (40 mg), and diphenhydramine syrup (160 mg) was prepared. Patients then used the dexamethasone mouthwash three times a day for 2 minutes each time, over a period of 14 days. No - There is not a plan to make this available Justification or reason for not sharing IPD is No further information available.
public Dr. Hamid Taherinia
Faculty of Dentistry, University Blvd., Arghwanieh, J Sharghi Street
Esfahan Iran (Islamic Republic of) 8595158 +98 31 3535 4003 taherinia@gmail.com Islamic Azad University, Khorasgan branch scientific Dr. Amir Mansour Shirani
Faculty of Dentistry, University Blvd., Arghwanieh, J Sharghi Street
Esfahan Iran (Islamic Republic of) 8595158 +98 31 3535 4003 shirani324@yahoo.com Islamic Azad University, Khorasgan branch Iran (Islamic Republic of) Informed consent Aged 18 years and older Clinical and pathological diagnosis of oral aphthous stomatitis or lichen planus Appropriate general health 18 years no limit Both Receipt of topical or systemic corticosteroids within the past three months Known hypersensitivity to betamethasone or dexamethasone Presence of severe or impactful systemic and underlying diseases (e.g., uncontrolled diabetes, renal failure, active cancer Use of corticosteroids and immunosuppressive agents History of oral fungal infections pregnancy or breastfeeding Tobacco use (cigarettes or hookah) K12.0 L43 Recurrent oral aphthae Lichen planus Treatment - Other Treatment - Other In the first intervention group, a combination of 6 vials of betamethasone ampoules, nystatin drops (100,000 units), aluminum hydroxide syrup (40 mg), and diphenhydramine syrup (160 mg) was prepared. Patients then used the betamethasone mouthwash three times a day for 2 minutes each time, over a period of 14 days. In the second intervention group, a combination of 6 vials of dexamethasone ampoules, nystatin drops (100,000 units), aluminum hydroxide syrup (40 mg), and diphenhydramine syrup (160 mg) was prepared. Patients then used the dexamethasone mouthwash three times a day for 2 minutes each time, over a period of 14 days. Pain intensity. Timepoint: Beginning of study and end of study. Method of measurement: Based on visual pain scale. Dry Mouth. Timepoint: Beginning of study and end of study. Method of measurement: Visit by a doctor. Allergy and oral fungus. Timepoint: Beginning of study and end of study. Method of measurement: Visit by a doctor. Islamic Azad University, Khorasgan branch Approved 2026-07-07 Ethics Committee of Islamic Azad University, Khorasgan branch Vice Chancellor for Research Affairs, University Blvd., Arghwanieh, J Sharghi Street Esfahan Isfehan Iran (Islamic Republic of)