IRCT20260807070559N1 IRCT 2026-08-10 Shiraz University of Medical Sciences investigating the Effect of Whey Protein on Radiation-Induced Dermatitis Effect of Oral Whey Protein (Mā’ al-Jubn) on Radiation-Induced Dermatitis in Breast Cancer Patients 2026-08-23 anticipated 100 Recruiting https://irct.ir/trial/92319 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: A permuted block randomization method with blocks of four will be used. There are six possible permutations for each block of four. Using a random-number table, a randomization list of 100 participants consisting of 25 blocks of four will be generated, determining the allocation sequence for the intervention and control groups, Blinding description: The whey protein supplement and placebo will be prepared in identical containers with respect to appearance, color, size, taste, and packaging, and will be labeled only with codes A and B. Based on the patient’s identification number and the randomization list, the radiation oncology resident will provide the assigned container to the patient. Supplement or placebo administration will begin on the first day of radiotherapy and continue until the last day of treatment. Patients and study assessors (the radiation oncology resident and specialist) will be blinded to the assigned intervention; therefore, the study will be conducted as a double-blind trial. Group allocation codes will remain confidential until completion of data collection and analysis. N/A Radiation-Induced Dermatitis. Intervention 1: Intervention group: Receiver of whey protein supplement. Intervention 2: Control group: Oral placebo recipient. No - There is not a plan to make this available Justification or reason for not sharing IPD is Individual participant data will not be shared because the study data are subject to patient confidentiality and privacy requirements. Only aggregated results will be reported.