]>
IRCT138706031079N1 IRCT 2011-08-09 Avicenna Research Institute; Tehran Medical Sciences University Co Q10 and Semen parameter Effect of Ubiquinone Supplementation on Semen Quality, Antioxidant Enzyme, Oxidative Stress and DNA Fragmentation in infertile men 2008-07-31 anticipated 60 Complete https://irct.ir/trial/93 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Male Infertility. Intervention 1: Co Q10 supplement: 2 (100 mg) per day (200 mg), 3 month,. Intervention 2: Placebo (lactose): 2 capsule per day, 3 month.
public Mohammad Reza Sadeghi
Avicenna Research Institute, Shahid Beheshti University , Evin, Tehran
Tehran Iran (Islamic Republic of) 1983969411 +98 21 2243 2024 sadeghi@avicenna.ac.ir Avicenna Resaerch Institute scientific Mohammad Reza Sadeghi
Avicenna Research Institute, Shahid Beheshti University , Evin
Tehran Iran (Islamic Republic of) 1983969411 +98 21 2243 2024 sadeghi@avicenna.ac.ir Avicenna Research Institute Iran (Islamic Republic of) Inclusion : idiopathic oligoasthenoteratospermia, normal profile for hormones, normal genital anatomy Exclusion: major infection in genital organ, treatment for systemic disease during the last three months of inclusion, surgery background on genitalia, exposure to chemicals ,solvents or heavy metals, supplementation therapy in last three months of inclusion 20 years 50 years Male N46 Male infertility Treatment - Drugs Treatment - Drugs Co Q10 supplement: 2 (100 mg) per day (200 mg), 3 month, Placebo (lactose): 2 capsule per day, 3 month Semen analysis. Timepoint: 45 days , 90days. Method of measurement: HPLC, flourometry , spectrophotometry, ELIZA. Sperm Isoprostan concentration. Timepoint: 45 days , 90days. Method of measurement: ELIZA. Activity of seminal plasma catalase. Timepoint: 45 days , 90days. Method of measurement: spectrophotometry. Activity of seminal plasma superoxide dysmutase. Timepoint: 45 days , 90days. Method of measurement: spectrophotometry. Seminal plasma ubiquinone concentration. Timepoint: 45 days , 90days. Method of measurement: HPLC. DNA fregmentation. Timepoint: 45 days , 90days. Method of measurement: Flowcytometry. Seminal plasma gluthation peroxidase. Timepoint: 45 days, 90 days. Method of measurement: spectrophotometry. Seminal plasma gluthation reductase. Timepoint: 45 days, 90 days. Method of measurement: spectrophotometry. Total Antioxidant Capacity(TAC). Timepoint: 45 days, 90 days. Method of measurement: spectrophotometry. Seminal plasma Coenzyme Q10. Timepoint: 45 days, 90 days. Method of measurement: HPLC. Avicenna Research Institute; Tehran Medical Sciences University Approved 2008-09-03 Avicenna Research Institute Avicenna Research Institute, Shahid Beheshti University , Evin, Tehran Tehran Iran (Islamic Republic of)