IRCT20251211068287N7 IRCT 2026-09-11 University of Tehran The impact of physical activity on the gut microbiome in breast cancer survivors The effect of 12 weeks of combined training (aerobic + resistance) on gut microbiome abundance, inflammatory markers, and psychological symptoms in breast cancer survivors 2026-09-23 anticipated 30 Pending https://irct.ir/trial/93128 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Education/Guidance, Randomization description: The randomization method in this study will be block randomization with variable block sizes (2 and 4), with the individual as the unit of randomization. The randomization sequence will be generated prior to the start of recruitment by a biostatistician using the online software Sealed Envelope. To ensure allocation concealment, sequentially numbered, opaque, sealed envelopes will be prepared by a researcher independent of the study team. After baseline assessments and obtaining informed consent, the next envelope will be opened in sequence to reveal the group assignment (exercise or control) for each participant. This is an open‑label trial, and no stratification will be applied in the randomization process. N/A Breast cancer survivors. Intervention 1: Intervention group: combine exercise training:The intervention duration is 12 weeks (resistance training: 30-35 minutes; aerobic training: 25-30 minutes). Sessions are conducted 3 times per week on non-consecutive days. Session duration: Each training session lasts approximately 60 to 70 minutes. Intervention 2: Control group: No regular physical activity. No - There is not a plan to make this available Justification or reason for not sharing IPD is IPD will not be shared due to ethical and privacy concerns, as the data include sensitive genomic and psychological information that could potentially compromise participant confidentiality even after de-identification. The study protocol and informed consent form do not include provisions for data sharing beyond the primary research team