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IRCT201707118872N12 IRCT 2017-07-23 Tehran University of Medical Sciences -Faculty of Medicine oral antibiotic effectiveness in prevention of wound infection in hand laceration Comparison of effectiveness of oral antibiotic with intravenous antibiotic in prophylaxis of wound infection in patients with hand laceration who come to emergency department 2017-07-27 anticipated 764 Complete https://irct.ir/trial/9354 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A hand laceration. Intervention 1: In intervention group, patients receive oral cephalexin per KG of body weight before procedure and receive normal saline as a placebo then discharged home with oral cephalexin for 48 hours. Intervention 2: In control group patients receive intravenous cefazolin per KG of body weight before procedure and patients receive an oral placebo similar to cephalexin capsules then discharged home with oral cephalexin for 48 hours.
public Morteza Saeedi
Shariati Hospital, North Amirabad street
Tehran Iran (Islamic Republic of) 1411713135 +98 21 8490 2717 m_saeedi@tums.ac.ir Tehran University of Medical Sciences scientific Dr. Morteza Saeedi
Shariati Hospital, North Amirabad street
Tehran Iran (Islamic Republic of) +98 21 8490 2717 m_saeedi@tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Inclusion Criteria: patients consent to participation in the study; patients with class 2 hand laceration whom treated by emergency physicians. Exclusion Criteria: patients with crash laceration; hand laceration accompanied by tendon injury that mandate patient admission; open fractures; bite wound; patient needed to admission to other services; laceration which needed to repair in operating room; allergic history to cephalosporins. no limit no limit Both s61.9 Open wound of wrist and hand part, part unspecified Treatment - Drugs Treatment - Drugs In intervention group, patients receive oral cephalexin per KG of body weight before procedure and receive normal saline as a placebo then discharged home with oral cephalexin for 48 hours. In control group patients receive intravenous cefazolin per KG of body weight before procedure and patients receive an oral placebo similar to cephalexin capsules then discharged home with oral cephalexin for 48 hours. Prevalence of wound infection. Timepoint: 48 hours after wound repair. Method of measurement: observation. Tehran University of Medical Sciences -Faculty of Medicine Approved 2016-10-04 Tehran University of Medical Siences floor 5, NO 226,Poursina avenue, Ghods avenue,Enghelab square, Tehran Tehran Iran (Islamic Republic of)