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IRCT201501049014N52 IRCT 2015-01-07 Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences Effect granulocyte colony stimulation factor (GCSF) versus placebo on implantation among infertile patients who underwent assisted reproductive technology (ART) Effect granulocyte colony stimulation factor (GCSF) versus placebo on implantation among infertile patients who underwent assisted reproductive technology (ART): a randomzed clinical trial 2013-11-22 anticipated 30 Complete https://irct.ir/trial/9491 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization: random assignment of the patients systematically one at a time to intervention and control groups. Blinding: Not blinded. 2 Infertility. Intervention 1: transvaginal injection of GCSF 300 IU, single dose, 2 or 5 days before embryo transfer. Intervention 2: prescription of OCP for 21 days plus 50 mcg GNRH agonist single dose on the 3rd day of menstrual period and 300 to 450 IU FSH or HMG, single dose, on the 14th day of menstrual period.
public Dr Zahra yazdi
Fatemieh Hospital, Pasdaran Ave.
Hamadan Iran (Islamic Republic of) +98 81 3827 7459 zyazdi88@yahoo.com Fatemieh Hospital scientific Dr Marzieh farimani
Fatemieh Hospital, Pasdaran Ave.
Hamadan Iran (Islamic Republic of) +98 81 3827 7459 farimanie@umsha.ac.ir Fatemieh Hospital Iran (Islamic Republic of) Inclusion criteria: (a) Infertile; (b) age of 20 to 40 years; (c) having determined factor such as endometriosis, myoma, or Asherman's syndrome. Exclusion criteria: (a) having cycle cell anemia, renal failure, upper or lower respiratory infection, or malignancy; (b) contraindication for pregnancy; (c) weak response rate. 20 years 40 years Female N97 Female infertility Treatment - Drugs Placebo transvaginal injection of GCSF 300 IU, single dose, 2 or 5 days before embryo transfer. prescription of OCP for 21 days plus 50 mcg GNRH agonist single dose on the 3rd day of menstrual period and 300 to 450 IU FSH or HMG, single dose, on the 14th day of menstrual period. Diagnosis of gestational sac and observation of embryo. Timepoint: 24 days after embryo transfer. Method of measurement: by transvaginal ultrasonography. Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences Approved 2014-05-17 Research Ethic Committee of Hamadan University of Medical Sciences Vice-chancellor of Research the Technology, Hamadan University of Medical Sciences, Shahid Fahmideh Ave Hamadan Hamadan Iran (Islamic Republic of)