IRCT201610289014N127 IRCT 2016-10-31 Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences Comparison of the effect of Primerose oil and Vitamin B6 versus placebo on premenstrual syndrome in girl college students Comparison of the effect of Primerose oil and Vitamin B6 versus placebo on premenstrual syndrome in girl college students: a double blind randomized clinical trial 2016-11-21 anticipated 120 Complete https://irct.ir/trial/9565 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization: The patients will be randomly assigned to intervention and control groups using block randomization. Blinding: Participants will be unaware of the type of intervention. The examiner who will examine the patients will not be aware of the intervention. Therefore, the trial will be run as double blind. 2 premenstrual syndrome. Intervention 1: Intervention group: Primerose oil capsule 1000 mg twice a day from 14 days before menstruation to 5 days after menstruation for two consecutive cycles. Intervention 2: Intervention group: Vitamin D capsule 40 mg twice a day from 14 days before menstruation to 5 days after menstruation for two consecutive cycles. Intervention 3: Control group: Placebo capsule twice a day from 14 days before menstruation to 5 days after menstruation for two consecutive cycles.