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IRCT201008161559N4 IRCT 2010-09-12 Research center of dental Science of Tehran University of medical sciences Comparative evaluation of low-power laser and co2 laser in treatment of oral lichen planus. Comparative evaluation of low-power laser and co2 laser in treatment of patients with oral lichen planus presenting to the oral Medicine Department at the Dentistry faculty in Tehran University of Medical Sciences in 1388-1389. 2009-04-04 anticipated 60 Complete https://irct.ir/trial/966 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A lichen planus. Intervention 1: Low power laser including red light (λ=633 nm, light exposure dose=0.3 J/cm2) and infrared light (λ=830 nm, light exposure dose=0.3 J/cm2) every other day for 5 sessions. Intervention 2: Co2 laser (λ=10600 nm, 20 W) at one session.
public Dr. Elham Moslemi
Oral medicine department of Tehran University of Medical Sciences, Ghods Ave., Keshavarz Blvd., Tehran, Iran
Tehran Iran (Islamic Republic of) +98 21 8838 4235 dr.emoslemi@yahoo.com Oral Medicine Department, Tehran University of Medical Sciences scientific Dr Farzaneh Aghahoseini
Oral medicine department, Tehran University of Medical Sciences, Ghods Ave., Keshavarz Blvd., Tehran, Iran
Tehran Iran (Islamic Republic of) +98 21 8338 4235 aghahose@ sina.tums.ac.ir Oral medicine department of Tehran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: clinical and histopathologic diagnosis of lichen planus with clinical criteria, consisting of the presence of symmetric reticular or papular lesions with or without erosive-atrophic components. Histopathologic features of oral lichen planus are: 1) Areas of hyperparakeratosis or hyperorthokeratosis, often with a thickening of the granular cell layer and a saw-toothed appearance to the retepages. 2) Liquefaction degeneration or necrosis of the basal layer. 3) A dense subepithelial band, shaped by infiltration of lymphocytes T and macrophages. 4) Absence of dysplastic changes. Exclusion criteria: Using drugs (including for the treatment of lichen planus at the first session) and exposure to amalgam fillings. no limit no limit Both L43 lichen planus Treatment - Other Treatment - Other Low power laser including red light (λ=633 nm, light exposure dose=0.3 J/cm2) and infrared light (λ=830 nm, light exposure dose=0.3 J/cm2) every other day for 5 sessions Co2 laser (λ=10600 nm, 20 W) at one session. Size of lesions. Timepoint: 2 weekly in the first month and then monthly for 3 months. Method of measurement: size of lesions with scaled tongue blade. Pain and discomfort in the oral lesions. Timepoint: 2 weekly in the first month and then monthly for 3 months. Method of measurement: VAS. Clinical score. Timepoint: 2 weekly in the first month and then monthly for 3 month. Method of measurement: Registration the primary scores of lesions and their changes on the follow up period as described in the material and method. Research center of dental Science of Tehran University of medical sciences Approved 2010-05-25 Dental Sciences Research center, Tehran University of Medical Sciences Dental Sciences Research center, Tehran University of Medical Sciences, Ghods Ave., Keshavarz Blvd., Tehran, Iran Tehran Iran (Islamic Republic of)