IRCT201204079399N1 IRCT 2012-11-15 Vice chancellor for research ,Kashan University of Medical Sciences A placebo-controlled clinical trial to assess efficacy of tranexamic acid in reducing hemorrhage after vaginal delivery A placebo-controlled clinical trial to assess efficacy of tranexamic acid in reducing hemorrhage after vaginal delivery 2012-11-10 anticipated 200 Complete https://irct.ir/trial/9921 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 2 postpartum hemorrhage. Intervention 1: In the experimental group , 1gram of tranexamic acid diluted in 20ml Dextrose 5% will be administered intravenously soon after neonatal delivery. Blood pressure, pulse rate will be checked, 1 hour and 2 hours after delivery. Hemoglobin levels will be measured promptly at the time of admission and also 24 hours after delivery.The studied parturients will be evaluated 24 hours after normal vaginal delivery in terms of drug induced complications . Maternal outcomes such as need to transfusion , surgery ,hysterectomy or death if occur will be documented . Intervention 2: In the control group , 20ml Dextrose 5% and placebo(normal saline) will be administered intravenously soon after neonatal delivery. Blood pressure, pulse rate will be checked, 1 hour and 2 hours after delivery.Hemoglobin levels will be measured promptly at the time of admission and also 24 hours after delivery. The studied parturients will be evaluated 24 hours after normal vaginal delivery in terms of drug induced complications . Maternal outcomes such as need to transfusion , surgery ,hysterectomy or death if occur will be documented .