<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT201603039460N2</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2016-03-31</date_registration>
      <primary_sponsor>Shahid beheshti university</primary_sponsor>
      <public_title>comparing effect of traditional continuous training and high intensity interval training on cardiac morphology and function</public_title>
      <acronym></acronym>
      <scientific_title>comparing effect of traditional continuous training and high intensity interval training on cardiac hypertrophic indexes, PI3k gene expression and cardiac function</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2014-09-21</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>36</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/9989</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: we use random numbers table to assigning subjects into three groups randomly.</study_design>
      <phase>N/A</phase>
      <hc_freetext>healthy subjects which participate in physical activity.</hc_freetext>
      <i_freetext>Intervention 1: Intervention 1: HIT group Exercises included warm up, HIT training, cool down. Subjects warmed up by stretching and easy walking for 5 minutes. The HIT interventions consisted of four 30 s maximal effort (“all-out”) shuttle run bouts (from cone-1 to cone-2 ,20 meter sweep) separated by 1.5 min passive rest each .&#13;
HIT protocol began with 4 cycles/session and every two weeks added one cycle. Finally it was 8 cycles/session in tenth week that lasted 16 minutes. Cooling Down also included 5 min of walking and stretching. During the HIT interventions all subjects were vocally encouraged to maintain Maximal effort. Intervention 2: Intervention 2:  consists of 20 minutes of running continuously at heart rate of approximately 140 continuously that started three sessions per week for fourth weeks and gradually increased in tenth week to 40 minutes. Intervention 3: control: Control group asked to be sedentary in this period.</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan></results_IPD_plan>
      <results_IPD_description></results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>arash saadatnia</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Shahid Beheshti University, Velenjak, Tehran, I.R. IRAN</address>
        <city>tehran</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>1983969411</zip>
        <telephone>+98 212293615</telephone>
        <email>arash.denatation@gmail.com</email>
        <affiliation>Shahid Beheshti University</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>khosrow ebrahim</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Shahid Beheshti University, Velenjak, Tehran, I.R. IRAN</address>
        <city>tehran</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>1983969411</zip>
        <telephone>+98 212294323</telephone>
        <email>k-ebrahim@sbu.ac.ir</email>
        <affiliation>Shahid Beheshti University</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Iran (Islamic Republic of)</country2>
    </countries>
    <criteria>
      <inclusion_criteria>inclusion criteria include age between-30, male gender and being in BMI normal range. Exclusion criteria include professional athletics history as well as the current regular exercise, smoking, cardiovascular and metabolic disease or any complication that disrupt the implementation of exercise</inclusion_criteria>
      <agemin>20 years</agemin>
      <agemax>30 years</agemax>
      <gender>Male</gender>
      <exclusion_criteria></exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code>Z00.8</hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword>Health examination in population surveys</hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Other</i_code>
      <i_code>Other</i_code>
      <i_code>Other</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>Intervention 1: HIT group Exercises included warm up, HIT training, cool down. Subjects warmed up by stretching and easy walking for 5 minutes. The HIT interventions consisted of four 30 s maximal effort (“all-out”) shuttle run bouts (from cone-1 to cone-2 ,20 meter sweep) separated by 1.5 min passive rest each .&#13;
HIT protocol began with 4 cycles/session and every two weeks added one cycle. Finally it was 8 cycles/session in tenth week that lasted 16 minutes. Cooling Down also included 5 min of walking and stretching. During the HIT interventions all subjects were vocally encouraged to maintain Maximal effort.</i_keyword>
      <i_keyword>Intervention 2:  consists of 20 minutes of running continuously at heart rate of approximately 140 continuously that started three sessions per week for fourth weeks and gradually increased in tenth week to 40 minutes.</i_keyword>
      <i_keyword>control: Control group asked to be sedentary in this period.</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>VO2max. Timepoint: pre intervention- post intervention. Method of measurement: Bruce treadmill test.</prim_outcome>
      <prim_outcome>Stroke Volume. Timepoint: pre intervention- post intervention. Method of measurement: echocardiography.</prim_outcome>
      <prim_outcome>Ejection Fraction. Timepoint: pre intervention- post intervention. Method of measurement: echocardiography.</prim_outcome>
      <prim_outcome>Left ventricle volume. Timepoint: pre intervention- post intervention. Method of measurement: echocardiography.</prim_outcome>
      <prim_outcome>End of systolic volume. Timepoint: pre intervention- post intervention. Method of measurement: echocardiography.</prim_outcome>
      <prim_outcome>End of diastolic volume. Timepoint: pre intervention- post intervention. Method of measurement: echocardiography.</prim_outcome>
      <prim_outcome>Inter ventricular septum. Timepoint: pre intervention- post intervention. Method of measurement: echocardiography.</prim_outcome>
      <prim_outcome>Plasma IGF-I levels. Timepoint: pre intervention- post intervention. Method of measurement: ELISA Kit.</prim_outcome>
      <prim_outcome>PI3K activity. Timepoint: pre intervention- post intervention. Method of measurement: ELISA Kit.</prim_outcome>
      <prim_outcome>P110δ Gene expression in luekocytes. Timepoint: pre intervention- post intervention. Method of measurement: PCR.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome></sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>Shahid beheshti university</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2013-09-21</approval_date>
        <contact_name>Ethics committee of  Ferdowsi University of Mashhad, Mashhad, Iran</contact_name>
        <contact_address>Azadi ave mashhad  Iran (Islamic Republic of)</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
