Study of low dose intrathecal meperidine on intra- and post-operative shivering in caesarean section under spinal anesthesia:a prospective double-blind, randomized Clinical Trial

The aim of this double-blind, randomized clinical trial study is to demonstrate the incidence and intensity of intra- and post-operative shivering on Seventy parturients;American Society of Anesthesiologists (ASA) physical status I to II; aged 18 to 40 years who will refer to Jahrom University of Medical Sciences educational hospitals for elective cesarean section under spinal anesthesia. We will exclude those Parturients who had contraindication to the local anesthesia and caesarean section surgery, diabetes, preoperative body temperature>38 C(fever), sever preeclampsia, allergy to the study medications (meperidine and bupivacaine); ASA III and higher.We will enroll 70 parturients into the study and will divide them into two groups, randomly. The parturients in case group will receive 10 mg bupivacaine 0.5% plus 10 mg meperidine and those in control group will receive 10 mg bupivacaine 0.5% plus 10 mg normal saline as a placebo. Finally, all data will be collected by a blinded observer.

Vice-chancellor for research -Jahrom University of Medical Sciences