The aim of this study was investigating the effects of transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) on cue-induced craving in abstinence methamphetamine-dependent patients. Present study, is a randomized, double-blind, sham-controlled, cross-over study. 32 Subjects were selected from Methamphetamine abusers, which were referred for treatment in the Vardij Therapeutic Community Center which is a specialized center for stimulants. Initially, subjects are examined in terms of inclusion and exclusion criteria. If they were eligible, then they would be taken of demographic information and informed consent. Inclusion criteria; having a history of at least 12 months methamphetamine dependence, being abstinence from any drugs except cigarettes, at least for the last week and having cue reactivity for cue-induced craving. Also exclusion criteria that the patient should not be eligible include: history of epilepsy; brain surgery, tumor, clinically significant head trauma. This study is a crossover design and the active stimulation compared with sham stimulation. At first, the subjects were randomly assigned to an intervention block; Active-Sham stimulations or Sham-Active stimulations. If someone received sham stimulation in the first session, he would receive active stimulation in the next session and vice versa. Washout period between 2 session interventions was at least 72-h, to avoid the any potentially carryover effects due to previous stimulation. In the active stimulation (active tDCS), the anode electrode was placed on the right dorsolateral prefrontal cortex (rDLPFC), and cathode on the left supraorbital area, whereas 2 mA direct current was passed through the subject's skull for 20 minutes. For sham stimulation, the same methods of placing anode and cathode were used, however, the stimulator was ramped-up to 2mA in 30s, then gradually ramped-down to 0 mA over the period of 1 minute, and then turned off but the electrodes were on the scalp for 20 minutes and subjects were not informed that the device is turned off. Participants and the evaluating investigators (except the technician that applied tDCS) were blinded to the intervention type. Baseline craving assessed before and after brain stimulation, in the both sessions by Desire for Drug Questionnaire (DDQ) which is adapted for methamphetamine. Furthermore, Induced craving was evaluated online with a computerized cue-induced craving assessment Task (CCIC), which run for 10 minutes and included 20 cue-induced craving pictures and 5 neutral pictures.