Comparison of Traditional Iranian Medicine product (based on Celery and Anise seed) with metformin on oligomenorrhea in patients with polycystic ovary syndrome(PCOs)

This study is a triple-blind randomized clinical trial that will examin the effect of traditional medicine products based on celery and anise on oligomenorrhea treatment of patients with polycystic ovary syndrome and the effect of metformin in the treatment of these patients in comparison. 72 patients 18 to 40 years old with PCOs who will refer with oligomenorrhea complaint to the outpatient clinic of the academic center after confirming gynecologist and qualifying criteria, including the absence of other systemic diseases (such as diabetes, hyperprolactinemia, thyroid disorders Chronic liver, kidney, diseases and epilepsy) and lack of pregnancy and lactation will be in the study. The subjects were randomly divided into two groups of 36 persons (receiver anise and celery products and metformin). For all patients at the baseline, ultrasound of the uterus, ovaries and hormonal and biochemical diagnostic tests will be done. In the group receiving traditional medicine products,they will use 4.5 g celery and anise powder( 6capsules divided into 3 meals ) for two weeks. If the menstruation occurs at each stage of using the drug,the herbal drug will cut and one placebo capsule will be used after every meal. After purity, restart the herbal medication and this process is repeated 3 cycles. In the absence of menstrual like mensturation days herbal drug will cut and one placebo capsule will be used after every meal for two weeks. After four weeks of therapy(two-week using of herbal drug and waiting two weeks and using placebo),if the mensturation does not occur, re-start taking the herbal product. This process is repeated three times. In the group taking metformin,1500 mg metformin powder(6 capsules divided into 3 meals ) for two weeks . In the menstruation days and the menstruation waited days,one metformin powder(500mg) capsule will be used. The main out come of this study is occurance of menstural bleeding, the duration of bleeding, menstrual bleeding volume, menstrual cycle length and duration of treatment until the occurrence of bleeding.

Deputy of research and technology Tabriz University of Medical Sciences-Dr. Mohammad Rashidi.Tabriz-Gogasht street, Tabriz University of Medical Sciences-Central Building number 2-third floor-Deputy of research and technology.East Azarbaijan-Iran.phone number: 0098413335731- fax number:00984133344280 .www.tbzmed.ac.ir/Research-rashidi@tbzmed.ac.ir