Efficacy of premedication with ibuprofen on the success of lower alveolar nerve block with lidocaine in comparison with infiltration of articaine in symptomatic irreversible pulpitis.

Finding a way to induce deep anesthesia in marked teeth with irreversible pulpitis

In this triple blind randomized clinical trial, 88 patients referred to the Department of Endodontics, Faculty of Dentistry, Qazvin, with the first or second mandibular molars having the diagnose of irreversible pulpitis, randomly ,divided into four groups (22 patients in each group). For the purpose of blinding, a code is assigned to each group.

Patients referring to the faculty of dentistry of Qazvin University of Medical Sciences who have a history of spontaneous pain will be studied. pulpal vitality tests will be performed on the Intended tooth (Precusion test, electricl pulp test and Cold test). Patients are asked to determine their pain based on the Visual Analogue Scale (VAS). A 100-millimeter line is drawn and the patient is asked to show a degree of pain on it (patients with pain 66 and above will be included in the study.) Then written consent is received from all patients to participate in the research. None of the patients, the practitioner, and the statistician are aware of the contents of the capsules, and only the drug supplier is aware of the contents of the capsules. All capsules containing the drug or placebo have the same shape , color and size and have their own code. All injections are done by an endodontist. 15 minutes after both types of injection , the access cavity begins. In the group that received the IANB anesthesia, they are asked about their lips' anesthesia. In the group that received infiltration anesthesia,anesthetized soft tissue is checked with a explorer . If the pain is felt during the access cavity, the treatment process stops and the patient determines the degree of pain. In the event of a mild pain (21 mm or less) experienced by the patient, the anesthetic will be considered successful and otherwise anesthesia is considered unsuccessful and supplemental anesthetic injection will be performed. After completing pulpotomy, the patient is refereed to the general or specialized department to continue the treatment.

Lower mandibular molar with irreversible pulpitis

In groups 2 and 4, placebo capsules, in groups 1 and 3, 400 mg ibuprofen capsules are given to patients.30 minutes after the administration of the drug, patients receive anesthesia related to their group.Patients in the lidocaine group,received 1.8 mL of 2% lidocaine with epinephrine 1.100000 (Daroupakhsh, Iran) using standard block and Patients in the articaine group receive 1.8 ml of articaine 4% with Epinephrine 1.100000 (DeraPakhsh, Iran) by buccal infiltration.

pain

Private

From patients with symptomatic irreversible pulpitis referring to the Department of Endodontics, Faculty of Dentistry Qazvin, 88 patients will be randomly selected on the basis of win pepi software.

None of the patients, the practitioner, and the statistician are aware of the contents of the capsules, and only the manufacturer of the drug is aware of the contents of the capsules. All capsules containing the drug or placebo have the same shape and color and size and have their own code. In Group 1 and 2 placebo capsules, and in groups 3 and 4, ibuprofen 400 mg capsules are given to the patients.

All the information of the participants

Up to one year after the publication of the results

Free access to data for all people

Data will be available for designing further studies and meta-analyzes

To communicate with Ramezani masoumeh Mobile number:09129490407 Email:M269_ramezani@yahoo.com

Up to 2 weeks