Comparison the eradication rate of Helicobacter pylori (HP) between standard triple therapy regime and licorice root extract adding to triple therapy regime in patients with helicobacter pylori infection

Goal of study: The goal of this study is consideration of the eradication rate of Helicobacter Pylori (HP) through standard triple therapy regime in comparison with adding licorice root extract to this regime. Designing of study: Randomized, clinical trial. Inclusion criteria to study: if all patients during endoscopic procedure with have positive rapid urease test (RUT), providing that not having the following condition: pregnancy؛ Previous usage Antiacid or bismuth during recent a month ؛ Gastrointestinal (GI) bleeding؛ the usage of alcohol or substance ؛ advanced chronic disease. Exclusion criteria from study: lack of willingness to continue the treatment؛ suffering the illness that needs to consume another drug. Sample size: 120 patient. Methods & Intervention: patient with gastric disorder who need endoscopic procedure and having positive RUT for HP entering into this study and divided into 2 groups. First group(A) are treated by Clarithromycin (500 mg twice a day) + Amoxicillin (1 gr twice a day) + Omeprazole (20 mg twice a day) for 2 weeks and second group(B) are treated by licorice root extracts ( D-Reglis 1 tab twice a day) adding to previous regime for the same duration. After finishing the main period of treatment they receive maintaining 4 weeks by omeprazole. Following two weeks of not taking any type of medicine then every patient is tested by stool antigen. Ultimately eradication rate of HP are compare in two groups. Intervention time: 2 weeks Primary outcome: Compare eradication of HP infection by stool antigen of HP between 2 groups.

Vice chancellor for research, Qazvin University of Medical Sciences