Objectives: Regarding the role of inflammatory factors, hyperlipidemia in cardiovascular diseases in hemodialysis patients and lack of research on the effect of artichoke supplement on these factors in hemodialysis patients, the present study was aimed to determine the effects of this plant on lipid and inflammatory factors in patients Hemodialysis was designed. Entry criteria:History of hyperlipidemia in hemodialysis patient; with failure to control blood lipids (serum LDL ≥100 mg/dl ); with Age over 18 and under 70 years old; with dialysis 2-3 time weekly every times for 3-4 hours; with The patient's willingness to participate in the research; having a case in considered nephrology center
without exclusion criteria; BMI less than 18;Artichoke use at least one month before the start of the study; unwillingness to continue to cooperate or traveling or death; pregnancy and lactation; the development of side effects of drug; lack of medication over a week.According to the statistics consult , sample size is 15 patients in each group, taking in to account the loss of samples 20 patients in each group have been administered as the sample size. For all samples, a full explanation is given about the objectives and methodology of research and samples enrolled after written informed consent. All samples have a questionnaire on demographic characteristics, clinical course that has been set is completed. Then the patient randomly divided in to two groups receiving either placebo or products of artichoke. Based on the random sequences produced by statistics consult, samples randomly divided in to two groups ( capsules artichoke ) and placebo ( starch capsules ). For the double-blind study , collection cans artichoke supplement or placebo by someone other than the researcher encoded so the lack of knowledge of each group for the researcher can be improvised by each group. The samples will be asked to fast in the next visit to clinic. At baseline in fasting , in all the participating patients, 5 ml venous blood is taken before the intervention and height and weight were also measured. Intervention: In the intervention group, the samples receive artichoke capsules ( 320 mg) up to six weeks, twice daily ( 8 am and 8 pm ). In the same manner the placebo group receives placebo capsule containing starch ( 320 mg) and up to 2 weeks after the drugs have been followed. All samples in both intervention and control groups, routinely receive atorvastatin tablets. The samples will be asked not to change in their diet and physical activity during this study and inform researchers about any changes in their medications. Blood draw is done in the end of week 4 and 8 (after 14-12 hours of fasting ) The main outcome variables: The primary outcome is the reduction of serum LDL levels. Check triglycerides, total cholesterol, HDL, ESR, CRP and serum ferritin levels and serum iron and TIBC in the plan are secondary consequences that the change in percentage of all variables compared with the baselines determined at the week 4 and 8.