Evaluation of effects of combined of supplement with carnitine and coenzyme Q10, versus therapeutic lifestyle changes (TLC Diet) diet on cardiovascular risk factors, function and quality of life after angioplasty in patients with experience of myocardial infarction

The aim of this study is to evaluate of combined of supplement with carnitine and coenzyme Q10, versus therapeutic lifestyle changes (TLC Diet) diet on cardiovascular risk factors, function and quality of life after angioplasty in patient with experience of myocardial infarction. This is a 2 x 2 factorial design clinical trial with Sample size 128 that with simple randomization divided into 4 groups. Every group has 32 precipitant. The first group only will receive therapeutic Lifestyle Changes (TLC) diet and second group will receive only the supplement L-carnitin and coenzyme Q10 and third group will receive two supplement L-carnitin and coenzyme Q10 and therapeutic Lifestyle Changes diet then fourth group is control group that will receive usual care. For the first and second group, plus education a therapeutic lifestyle change diet is formulated based on individual patient characteristics. Patient in the second and third group, dietary supplement carnitine 1200 mg and co-enzyme Q10 150 mg will receive. This study is a single blind and investigator is aware of the type of intervention. Patients with a first myocardial infarction, primary angioplasty, and hyperlipidemia (LDL >130) are selected for intervention If the patient has history of warfarin consumption or angioplasty complication exclude in survey. Duration of intervention is 3 month. Before and after the intervention will measure inflammatory marker (CRP and IL 6) lipid profile (LDL, HDL, and TG), ejection fraction, physical activity and quality of life.

government source ,Shiraz University of Medical Sciences