The effect of ginger powder supplement on lipid profile, insulin resistance, antioxidant status, inflammatory biomarkers and fatty liver index in owerweight and obese patients with Nonalcoholic fatty liver disease(NAFLD).

The purpose of this study is to assess the effect of ginger powder supplement on lipid profile, insulin resistance, antioxidant status, inflammatory biomarkers and fatty liver index in overweight and obese patients with nonalcoholic fatty liver disease (NAFLD). In this randomized, double blind, placebo controlled trial with parallel design, 46 patients suffering from NAFLD will be selected among patients referring to Gastroenterology Clinic of Imam Khomeini Hospital in Ahvaz. Participants will be randomly assigned to intervention or control group (1:1 ratio) based on the blocked randomization method. The intervention group three capsules 500 mg ginger (1500 mg per day) and the control group will use placebo for 12 weeks. Inclusion criteria include Patients aged between 20 to 70 years who will be diagnosed with NAFLD by ultrasonography scan and increased levels of liver enzymes; and have a Body Mass Index (BMI) greater than 24.9 and lower than 35. Exclusion criteria for the study will be alcohol consumption; pregnant and lactating women; any forms of hepatic or metabolic disease except NAFLD; taking hepatotoxic drugs; using nutrition supplements and have any history of gastric bypass or intestine surgery. At the beginning and end of the study different variables of the study include blood levels of lipid profile, inflammatory and oxidative stress biomarkers, insulin resistance and liver enzymes will be measured.

Vice Chancellor for research of Ahvaz Jundishapur University of Medical Sciences