This study is aimed to compare the effect of acupressure method with treatment induced by Ondansetron and Metoclopramide on the postoperative nausea and vomiting after strabismus surgery. Two hundred patients, ASA physical status I or II, aged between 10 and 60 years, undergoing strabismus surgery in Farabi Hospital during 2007 to 2008, were included in this randomized, prospective, double-blind and placebo-controlled study. Patients were randomized into four groups of 50 each, using a table of random numbers. Group II patients received Metoclopramide, 0.2 mg/kg, IV just before induction. Group III patients received Ondansetron, 0.15 mg/kg, IV just before induction. In Group IV patients, acupressure bands were applied at the P6 point on both forearms 30 min before induction of anesthesia and removed after 6 hours. In Groups I, II and III, the spherical beads of the acupressure wrist bands were placed inappropriately on the posterior surface of both forearms 30 min prior to induction of anesthesia. Groups I and IV patients received normal saline 1 ml, IV just before induction of anesthesia to maintain blinding. Patients were followed up at the recovery (0-2 hr) and in the ward (2-24 hr) during first 24 hours and were assessed for PONV. Postoperative retching, nausea, and vomiting were recorded by nursing staff who were unaware of the type of treatment given to the patients.